Reference : In Vitro Activities of Strychnos Alkaloids and Extracts against Plasmodium Falciparum
Scientific journals : Article
Life sciences : Microbiology
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/5682
In Vitro Activities of Strychnos Alkaloids and Extracts against Plasmodium Falciparum
English
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Hayette, Marie-Pierre mailto [Université de Liège - ULg > > Microbiologie médicale >]
Tits, Monique mailto [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
De Mol, Patrick mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Sep-1999
Antimicrobial Agents and Chemotherapy
43
9
2328-31
Yes (verified by ORBi)
International
0066-4804
[en] Plasmodium falciparum ; Strychnos ; antiplasmodial activity
[en] The in vitro antimalarial activities of 46 alkaloids and extracts from Strychnos species were evaluated. Two types of quasidimeric alkaloids exhibit high and selective activities against Plasmodium. Strychnopentamine and isostrychnopentamine were active against chloroquine-sensitive and -resistant strains (50% inhibitory concentration [IC(50)] approximately 0.15 microM), while dihydrousambarensine exhibited a 30-fold higher activity against the chloroquine-resistant strain (IC(50) = 0.03 microM) than it did against the chloroquine-sensitive strain.
http://hdl.handle.net/2268/5682

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