Article (Scientific journals)
In Vitro Activities of Strychnos Alkaloids and Extracts against Plasmodium Falciparum
Frederich, Michel; Hayette, Marie-Pierre; Tits, Monique et al.
1999In Antimicrobial Agents and Chemotherapy, 43 (9), p. 2328-31
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Keywords :
Plasmodium falciparum; Strychnos; antiplasmodial activity
Abstract :
[en] The in vitro antimalarial activities of 46 alkaloids and extracts from Strychnos species were evaluated. Two types of quasidimeric alkaloids exhibit high and selective activities against Plasmodium. Strychnopentamine and isostrychnopentamine were active against chloroquine-sensitive and -resistant strains (50% inhibitory concentration [IC(50)] approximately 0.15 microM), while dihydrousambarensine exhibited a 30-fold higher activity against the chloroquine-resistant strain (IC(50) = 0.03 microM) than it did against the chloroquine-sensitive strain.
Disciplines :
Microbiology
Pharmacy, pharmacology & toxicology
Author, co-author :
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Hayette, Marie-Pierre ;  Université de Liège - ULiège > Microbiologie médicale
Tits, Monique ;  Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
De Mol, Patrick ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
In Vitro Activities of Strychnos Alkaloids and Extracts against Plasmodium Falciparum
Publication date :
September 1999
Journal title :
Antimicrobial Agents and Chemotherapy
ISSN :
0066-4804
eISSN :
1098-6596
Publisher :
American Society for Microbiology, Washington, United States - District of Columbia
Volume :
43
Issue :
9
Pages :
2328-31
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 February 2009

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