[en] The in vitro antimalarial activities of 46 alkaloids and extracts from Strychnos species were evaluated. Two types of quasidimeric alkaloids exhibit high and selective activities against Plasmodium. Strychnopentamine and isostrychnopentamine were active against chloroquine-sensitive and -resistant strains (50% inhibitory concentration [IC(50)] approximately 0.15 microM), while dihydrousambarensine exhibited a 30-fold higher activity against the chloroquine-resistant strain (IC(50) = 0.03 microM) than it did against the chloroquine-sensitive strain.
Disciplines :
Microbiology Pharmacy, pharmacology & toxicology
Author, co-author :
Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Angenot, L., Bisset, N.G., Isolement et structure de nouveaux alcaloïdes extraits du Strychnos usambarensis GILG du rwanda (1971) J. Pharm. Belg., 26, pp. 585-588
Angenot, L., Coune, C., Tits, M., Nouveaux alcaloïdes des feuilles du Strychnos usambarensis (1978) J. Pharm. Belg., 33, pp. 11-23
Angenot, L., Tits, M., Isolement d'un nouvel alcaloïde et d'un triterpénoïde à partir de Strychnos henningsii du Zaïre (1981) Planta Med., 41, pp. 240-243
Bisset, N.G., Das, B., Parello, J., Alkaloids from the leaves of Strychnos icaja Baill (1973) Tetrahedron, 29, pp. 4137-4148
Bonjean, K., De Pauw, M.C., Quetin-Leclercq, J., Angenot, L., Bassleer, R., In vitro cytotoxic activity of two potential anticancer drugs isolated from Strychnos: Strychnopentamine and usambarensine (1996) Anticancer Res., 16, pp. 1129-1138
Bosly, J., Etude des alcaloïdes du Strychnos Holstii (1951) J. Pharm. Belg., 6, p. 150
Caprasse, M., Tavernier, D., Anteunis, M., Angenot, L., Isolement de Nb-méthylantirhine, malindine et isomalindine à partir du Strychnos usambarensis (1984) Planta Med., 44, pp. 27-30
Desjardins, R., Canfield, C., Haynes, J., Chulay, J., Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique (1979) Antimicrob. Agents Chemother., 16, pp. 710-718
Frédérich, M., Quetin-Leclercq, J., GadiBiala, R., Brandt, V., Penelle, J., Tits, M., Angenot, L., 3′,4′,5′,6′ Tetradehydrolongicaudatine Y, an anhydronium base from Strychnos usambarensis (1998) Phytochemistry, 48, pp. 1263-1266
Frédérich, M., Tits, M., Hayette, M.P., Brandt, V., Penelle, J., De Mol, P., Llabrés, G., Angenot, L., 10′-Hydroxyusambarensine, a new bisindole alkaloid from the roots of Strychnos usambarensis (1999) J. Nat. Prod., 62, pp. 619-621
Kambu, K., Coune, C., Angenot, L., Nouveaux alcaloïdes des racines du Strychnos icaja (1979) Planta Med., 37, pp. 161-164
Leclercq, J., DePauw, M.C., Bassleer, R., Angenot, L., Screening of cytotoxic activities of Strychnos alkaloids (1986) J. Ethnopharmacol., 15, pp. 305-316
Mirovsky, P., Gay, F., Bustos, D., Mazier, D., Gentilini, M., Cloning of a fresh isolate of Plasmodium falciparum and drug sensitivity of the clones (1990) Trans. R. Soc. Trop. Med. Hyg., 84, pp. 511-515
Quetin-Leclercq, J., Llabrès, G., Warin, R., Belem-Pinheiro, M., Mavar-Manga, H., Angenot, L., Guianensine, a zwitterionic alkaloid from Strychnos guianensis (1995) Phytochemistry, 40, pp. 1557-1559
Quetin-Leclerq, J., Tits, M., Angenot, L., Bisset, N.G., Alkaloids of Strychnos usambarensis stem bark (1991) Planta Med., 57, pp. 501-502
Trager, W., Jensen, J.B., Human malaria parasites in continuous cultures (1976) Science, 193, pp. 673-675
Wright, C.W., Allen, D., Cai, Y., Chen, Z., Phillipson, J.D., Kirby, G., Warhurst, D., Angenot, L., Selective antiprotozoal activity of some Strychnos alkaloids (1994) Phytother. Res., 8, pp. 149-152