Reference : Five labdane diterpenoids from the seeds of Aframomum zambesiacum
Scientific journals : Article
Life sciences : Phytobiology (plant sciences, forestry, mycology...)
Life sciences : Biochemistry, biophysics & molecular biology
Five labdane diterpenoids from the seeds of Aframomum zambesiacum
Kenmogne, Marguerite [University of Dschang (Cameroun) > Faculty of Science > Department of Chemistry >]
Prost, Elise [Université de Reims Champagne-Ardenne - URCA >]
Harakat, Dominique [Université de Reims Champagne-Ardenne - URCA > Faculté des Sciences > Laboratoire "Réactions Sélectives et Applications’’ > UMR CNRS 6519 >]
Jacquier, Marie-José [Université de Reims Champagne-Ardenne - URCA >]
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Sondengam, Lucas B. [University of Yaoundé I > Faculty of Science > Department of Organic Chemistry >]
Zèches, Monique [Université de Reims Champagne-Ardenne - URCA >]
Waffo-Téguo, Pierre [Université de Reims Champagne-Ardenne - URCA >]
Pergamon-Elsevier Science Ltd
Yes (verified by ORBi)
[en] Aframomum zambesiacum ; Zingiberaceae ; labdane diterpenoids ; antiplasmodial activity ; Plasmodium falciparum
[en] Five labdane diterpenoids, (3-5), zambesiacolactone A (7) and zambesiacolactone B (8), were isolated from the seeds of Aframomum zambesiacum (Baker) K. Schum., along with five known labdanes and a linear sesquiterpene, nerolidol. Their structures were elucidated by spectroscopic analysis. Their antiplasmodial activity was evaluated in vitro against Plasmodium falciparum. Compound 3 was the most active with an IC50 value of 4.97 mu M. (c) 2005 Elsevier Ltd. All rights reserved.

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