Reference : Delayed reepithelialization and scarring deregulation following drug-induced toxic ep...
Scientific journals : Article
Human health sciences : Dermatology
http://hdl.handle.net/2268/5663
Delayed reepithelialization and scarring deregulation following drug-induced toxic epidermal necrolysis.
English
Paquet, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Jacob, E. [Centre Hospitalier Universitaire de Liège - CHU >]
Quatresooz, Pascale mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Jacquemin, Denise mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie maxillo-faciale et plastique >]
Pierard, Gérald mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
2007
Burns
Elsevier
33
1
100-4
Yes (verified by ORBi)
International
0305-4179
New York
NY
[en] Allopurinol/adverse effects ; Antimetabolites/adverse effects ; Cicatrix, Hypertrophic/chemically induced/pathology ; Epidermal Necrolysis, Toxic/etiology/pathology ; Female ; Humans ; Keratinocytes/transplantation ; Lupus Erythematosus, Systemic/drug therapy/pathology ; Middle Aged ; Skin Transplantation/methods/pathology ; Transplantation, Homologous
[en] A 51-year-old Caucasian woman developed severe drug-induced toxic epidermal necrolysis (TEN) due to allopurinol. The withdrawal of the culprit drug was unfortunately delayed, and dramatic retardation of reepithelialization was observed. At that stage of disease evolution, an inflammatory cell infiltrate was present in the dermis. Coverage of eroded lesions by frozen cultured keratinocyte allografts failed to hasten reepithelialization compared to ungrafted sites. This unusual protracted TEN evolution was followed by the development of extensive hypertrophic and keloid scars. Several biopsies were taken over 6 months. The histologic presentation of the grafted and ungrafted eroded scar tissues looked similar. Both the number and size of the Factor XIIIa-positive dermal dendrocytes, as well as the number of alpha-actin-positive myofibroblasts showed a marked increase between weeks 2 and 12 after grafting. They were reduced after 6 months when the scarring process was stabilized. alpha1 [IV] collagen was never expressed over the eroded scars. Similar to burn patients, delayed reepithelialization might be a risk factor for abnormal scarring in TEN. Cultured keratinocyte allograft apparently offered no improvement in reepithelialization and did not prevent abnormal scarring in this TEN patient.
http://hdl.handle.net/2268/5663
10.1016/j.burns.2006.04.031

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