Reference : Effects of Strychnopentamine on Cells Cultured in Vitro
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Human health sciences : Pharmacy, pharmacology & toxicology
Effects of Strychnopentamine on Cells Cultured in Vitro
Quetin-Leclercq, J. [> > > >]
De Pauw-Gillet, Marie-Claire mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Bassleer, Roger [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]
Chemico-Biological Interactions
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[en] strychnopentamine ; cytotoxic activity ; cytology
[en] This paper describes the powerful cytotoxic action exerted by strychnopentamine (SP), a dimeric indole alkaloid extracted from Strychnos usambarensis Gilg, on B16 melanoma cells and on non-cancer human fibroblasts cultured in vitro. SP strongly inhibits cell proliferation and induces cell death at a relatively low concentration (less than 1 microgram/ml) after 72 h of treatment in the two lines. Incorporation of [3H]thymidine and [3H]leucine by B16 cells significantly decreases after only 1 h of treatment at 0.5 microgram/ml. SP induces the formation of dense lamellar bodies and vacuolization in the cytoplasm, intense blebbing at the cell surface and various cytological alterations leading to cell death.

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Chem. Biol. Interactions 80 (1991) pp 203_216.pdfPublisher postprint864.26 kBRequest copy

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