You are here:
| Reference : Effects of Strychnopentamine on Cells Cultured in Vitro |
| Scientific journals : Article | |||
| Life sciences : Anatomy (cytology, histology, embryology...) & physiology Human health sciences : Pharmacy, pharmacology & toxicology | |||
| http://hdl.handle.net/2268/56153 | |||
| Effects of Strychnopentamine on Cells Cultured in Vitro | |
| English | |
| Quetin-Leclercq, J. [> > > >] | |
Gillet, Marie-Claire  [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques >] | |
| Angenot, Luc [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >] | |
| Bassleer, Roger [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >] | |
| 1991 | |
| Chemico-Biological Interactions | |
| 80 | |
| 2 | |
| 203-16 | |
| International | |
| 0009-2797 | |
| [en] strychnopentamine ; cytotoxic activity ; cytology | |
| [en] This paper describes the powerful cytotoxic action exerted by strychnopentamine (SP), a dimeric indole alkaloid extracted from Strychnos usambarensis Gilg, on B16 melanoma cells and on non-cancer human fibroblasts cultured in vitro. SP strongly inhibits cell proliferation and induces cell death at a relatively low concentration (less than 1 microgram/ml) after 72 h of treatment in the two lines. Incorporation of [3H]thymidine and [3H]leucine by B16 cells significantly decreases after only 1 h of treatment at 0.5 microgram/ml. SP induces the formation of dense lamellar bodies and vacuolization in the cytoplasm, intense blebbing at the cell surface and various cytological alterations leading to cell death. | |
| http://hdl.handle.net/2268/56153 |
| File(s) associated to this reference | ||||||||||||||
|
Fulltext file(s):
| ||||||||||||||
All documents in ORBi are protected by a user license.
