ORBi: Ouattara Badiore - Antisickling properties of divanilloylquinic acids isolated from Fagara zanthoxyloides Lam. (Rutaceae).

Reference : Antisickling properties of divanilloylquinic acids isolated from Fagara zanthoxyloides L...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology Life sciences : Phytobiology (plant sciences, forestry, mycology...)
	To cite this reference:	http://hdl.handle.net/2268/5614

Title :	Antisickling properties of divanilloylquinic acids isolated from Fagara zanthoxyloides Lam. (Rutaceae).
Language :	English
Author, co-author :	Ouattara, Badiore [Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou > Département Médecine-Pharmacopée Traditionnelle / Pharmacie > > >]
	Jansen, Olivia [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
	Angenot, Luc [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
	Guissou, Pierre [Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou > Département Médecine-Pharmacopée Traditionnelle / Pharmacie > > >]
	Frederich, Michel [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
	Fondu, Pierre [Université Libre de Bruxelles - ULB > Hôpital Universitaire Brugmann > > >Laboratoire d'Hématologie, > >]
	Tits, Monique [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
Publication date :	Mar-2009
Journal title :	Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Publisher :	Elsevier
Volume :	16
Issue/season :	2-3
Pages :	125-129
Audience :	International
e-ISSN :	1618-095X
Keywords :	[en] Fagara zanthoxyloides ; Burkinabins A, B, C ; divanilloylquinic acids ; sickle cell disease ; Rutaceae
Abstract :	[en] Fagara zanthoxyloides Lam. (syn. Zanthoxylum zanthoxyloides) (Rutaceae) is the most cited Fagara species for the treatment and the prevention of sickle cell disease crisis. Sickle cell anemia (SCA) is a public health problem in many countries particularly in Africa. The present study was designed to evaluate the antisickling properties of three isomeric divanilloylquinic acids (3,4-O-divanilloylquinic acid or burkinabin A; 3,5-O-divanilloylquinic acid or burkinabin B and 4,5-O-divanilloylquinic acid or burkinabin C) identified previously by LC/MS/NMR analysis in the root bark of F. zanthoxyloides [Ouattara et al., 2004. LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam. Phytochemistry 65, 1145-1151]. The three isomers showed interesting antisickling properties which increased from burkinabins A to C.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/5614
DOI :	10.1016/j.phymed.2008.10.013

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