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| Reference : Lessons from Ontarget |
| Scientific journals : Article | |||
| Human health sciences : Multidisciplinary, general & others Human health sciences : Urology & nephrology | |||
| http://hdl.handle.net/2268/5606 | |||
| Lessons from Ontarget | |
| English | |
| Berlaimont, V. [Boehringer-Ingelheim, Brussels > Medical Department > > >] | |
| Billiouw, J.-M. [Onze-Lieve-Vrouw Ziekenhuis, Aalst > Nephrology > > >] | |
| Brohet, C. [Cliniques Universitaires Saint-Luc (Bruxelles) > Cardiologie > > >] | |
| Dupont, A. G. [Universitair Zienkenhuis Brussel, Brussel > Departement of Clinical Pharmacology and Pharmacotherapy > > >] | |
| Gazagnes, M.-D. [Centre Universitaire Brugmann, Bruxelles > Departement of Neurology > > >] | |
| Heller, F. [Centre Hospitalier Jolimont-Lobbes, Haint-St-Paul > Department of Internal Medicine > > >] | |
Krzesinski, Jean-Marie  [Université de Liège - ULg > Département des sciences cliniques > Néphrologie >] | |
| Missault, L. [Algemeen Ziekenhuis St-Jan, Brugge > Department of Cardiology > > >] | |
| Persu, A. [Cliniques Universitaires Saint-Luc (Bruxelles) > Cardiologie > > >] | |
| Pierard, Luc [Université de Liège - ULg > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation >] | |
| Rottiers, R. [Universitair Ziekenhuis Gent - UZ > Department of Endocrinology > > >] | |
| Vanhooren, G. [Algemeen Ziekenhuis St-Jan, Brugge > Department of Neurology > > >] | |
| Van Mieghem, W. [Zienkenhuis Oost-Limburg, Genk > Department of Cardiology > > >] | |
| Vervaet, P. [Boehringer-Ingelheim, Brussels > Medical Department > > >] | |
| Herman, A. G. [Universiteit van Antwerpen, Antwerpen, Belgium > Division of Pharmacology > > >] | |
| 2008 | |
| Acta Clinica Belgica | |
| Acta Clinica Belgica | |
| 63 | |
| 3 | |
| 142-151 | |
| Yes (verified by ORBi) | |
| National | |
| 0001-5512 | |
| Bruxelles | |
| Belgique | |
| [en] ONTARGET trial ; cardiovascular ; telmisartan ; ramipril ; RAAS | |
| [en] The recently published results of the ONTARGET trial shed a new light on the cardiovascular protection of patients at high risk of a cardiovascular event. Despite a number of trials looking at the efficacy of Angiotensin Converting Enzyme inhibitors (ACEis) or Angiotensin Receptor Blockers (ARBs) in the prevention of cardiovascvular events in patients with specific high risk profiles, the question of the equivalence of ACEis and ARBs remained unanswered. The ONTARGET trial has shown that telmisartan 80 mg administered for a median duration of 4.5 years to patients at high risk of developing a major cardiovascular event, is equally effective to ramipril 10 mg. In addition, telmisartan was slightly better tolerated. The comparator ramipril has been chosen as it is currently the gold standard ACEi since the results of the HOPE study, in terms of the composite outcome of cardiovascular death, myocardial infarction and stroke. Moreover, ONTARGET is the first trial to test the hypothesis of superiority of adding an ARB (telmisartan 80 mg) to an ACEI (ramipril 10 mg) over the ACEi ramipril monotherapy in cardiovascular protection of the same broad range of high-risk patients. Surprisingly, despite a more pronounced blood pressure lowering, the combination of the two agents did not lead to an additional decrease in the number of events, but had significantly more side-effects compared to ramipril monotherapy. ONTARGET is a landmark study, performed according to the highest statistical and clinial standards, providing compelling evidence and clear answers to two important clinical questions. | |
| Researchers ; Professionals ; Students ; Others | |
| http://hdl.handle.net/2268/5606 | |
| www.actaclinicabelgica.be |
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