Reference : Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis JF...
Scientific journals : Article
Life sciences : Phytobiology (plant sciences, forestry, mycology...)
Physical, chemical, mathematical & earth Sciences : Chemistry
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/5600
Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis JF Gmel (Combretaceae)
English
Fiot, Julien [> Université Aix Marseille II > > Pharmacie > Pharmacognosie > >]
Sanon, Souleymane [> Université de Ouagadougou > > > > > >]
Azas, Nadine [> Université Aix Marseille II > Pharmacie > Parasitologie > >]
Mahiou, Valérie [> Université Aix Marseille II > > Pharmacie > Pharmacognosie > >]
Jansen, Olivia mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Balansard, Guy [> Université Aix Marseille II > > Pharmacie > Pharmacognosie > >]
Ollivier, Evelyne [> Université Aix Marseille II > > Pharmacie > Pharmacognosie > >]
30-Jun-2006
Journal of Ethnopharmacology
Elsevier Ireland Ltd
106
2
173-178
Yes (verified by ORBi)
International
0378-8741
Clare
[en] Guiera senegalensis ; antiplasmodial activity ; cytotoxicity ; beta-carboline ; guieranone A
[en] The chemical composition of total alkaloids from leaves and roots of Guiera senegalensis was investigated. Three beta-carboline alkaloids were purified: in addition to harman and tetrahydroharman, known in roots and leaves. harmalan (dihydroharman) was isolated for the first time from roots of Guiera senegalensis. Guieranone A, a naphthyl butenone, was also purified from leaves and roots. The in vitro antiplasmodial activity and the cytotoxicity of extracts and pure compounds were evaluated. Each total alkaloid extract and beta-carboline alkaloids presented an interesting antiplasmodial activity associated with a low cytotoxicity. Harmalan was less active than harman and tetrahydroharman. Guieranone A showed a strong antiplasmodial activity associated with a high cytotoxicity toward human monocytes. Its cytotoxicity was performed against two cancer cell lines and normal skin fibroblasts in order to study its anticancer potential: guieranone A presented a strong cytotoxicity against each cell strains. Finally, we evaluated the potent synergistic antimalarial interaction between Guiera senegalensis and two plants commonly associated in traditional remedies: Mitragyna inermis and Pavetta crassipes. Three associations evaluated were additive. A synergistic effect was shown between total alkaloids extracted from leaves of Guiera senegalensis and those of Mitragyna inermis. This result justified the traditional use of the plants in combination to treat malaria. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Researchers ; Professionals
http://hdl.handle.net/2268/5600

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