Reference : Screening of 14 alkaloids isolated from Haplophyllum A. Juss. for their cytotoxic proper...
Scientific journals : Article
Life sciences : Phytobiology (plant sciences, forestry, mycology...)
Physical, chemical, mathematical & earth Sciences : Chemistry
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/5597
Screening of 14 alkaloids isolated from Haplophyllum A. Juss. for their cytotoxic properties
English
[fr] Evaluation de la cytotoxicité de 14 alcaloïdes isolés du genre Haplophyllum A. Juss.
Jansen, Olivia mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Akhmedjanova, Valentina [Uzbek Academy of Sciences > Yunusov Institute of the Chemistry of Plant Substances > > >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Balansard, Guy [> Université Aix Marseille II > > > Pharmacie > Pharmacognosie > >]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Ollivier, Evelyne [> Université d'Aix Marseille II > > Pharmacie > Pharmacognosie > >]
Tits, Monique mailto [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
21-Apr-2006
Journal of Ethnopharmacology
Elsevier Ireland Ltd
105
1-2
241-245
Yes (verified by ORBi)
International
0378-8741
Clare
[en] Rutaceae ; Haplophyllum ; quinoline alkaloid ; cytotoxicity ; haplamine
[en] Further to a systematic chemotaxonomic study of Uzbek Haplophyllum A. Juss. plants selected on ethnopharmacological data, 14 alkaloids were screened for their cytotoxic properties. As a first selection for interesting compounds, each alkaloid was tested against two human cancer cell lines (HeLa and HCT-116), using WST-1 reagent. Of the 14 alkaloids, 5 were cytotoxic when tested against the HeLa line with an IC50 < 100 microM. These five compounds consisted of three furoquinolines: skimmianine; haplopine and gamma-fagarine and two pyranoquinolones: flindersine and haplamine. Only haplamine was active against the HCT-116 line. The cytotoxic properties of these five alkaloids were further investigated against five additional human cancer cell lines. Their structure-activity relationships will be discussed. Of these five pre-selected alkaloids, only haplamine showed significant cytotoxic activity against all the tested cell lines. This is the first report of the cytotoxic activity of haplamine. Finally, this pyranoquinolone alkaloid was tested here against 14 different cancer cell lines and against normal skin fibroblasts.
CIRM - Laboratoire de Pharmacognosie - Laboratoire de chimie médicale
Researchers ; Professionals
http://hdl.handle.net/2268/5597
10.1016/j.jep.2005.11.001

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