[en] VALAPODYN is a research network funded by the European Commission
(6th Framework Program) which is developing an original systems
biology approach focused on the development of multidisciplinary
functional genomics related to complex biological processes and cellular
networks. The aim is to generate an innovative approach to model
the dynamics of molecular interaction networks (MIN) in relation to cell
death and survival to detect new therapeutic targets to treat human
brain diseases. The project consists of fundamental genomics research
which is integrating statistical data analysis with real biological
data in order to functionally annotate genes and proteins. Specialized
genomics and proteomics databases for MIN modeling are being used
along with leading microarray and proteomics platform systems to investigate
protein-protein interactions and regulation networks. This will
help to identify and validate biological targets in complex intracellular
pathways to cure multifactorial diseases. Dynamic modeling specifically
addresses the systems biology of complex cellular pathways and
transcriptional networks. The novel dynamic models will be validated
by testing the selected drug targets on innovative in vivo and in vitro
models of CNS pathologies.
As opposed to most current biological data analysis methods, VALAPODYN
develops a dynamic and quantitative analysis method for
new therapeutic targets through MIN dynamic models. It will provide
a cutting-edge highly accurate in silico tool for identifying novel and
effective therapeutic targets in a much faster, more efficient and more
economical way than it is possible today. (www.valapodyn.eu).
Research center :
CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège