Reference : HPLC quantification of alkaloids from Haplophyllum extracts and comparison with their...
Scientific journals : Article
Life sciences : Phytobiology (plant sciences, forestry, mycology...)
Physical, chemical, mathematical & earth Sciences : Chemistry
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/5546
HPLC quantification of alkaloids from Haplophyllum extracts and comparison with their cytotoxic properties
English
Fiot, Julien [> Université Aix Marseille II > > > Pharmacie > Pharmacognosy > >]
Jansen, Olivia mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Akhmedjanova, Valentina [> Academy of Sciences (Uzbekistan) > > > Yunusov Institute of the Chemistry of Plant substances > > >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Balansard, Guy [>Université Aix Marseille II > > > Pharmacie > Pharmacognosie > >]
Ollivier, Evelyne [> Université Aix Marseille II > > > Pharmacie > Pharmacognosie > >]
Sep-2006
Phytochemical Analysis
John Wiley & Sons Ltd
17
5
365-369
Yes (verified by ORBi)
International
0958-0344
Chichester
[en] HPLC ; haplopine ; skimmianine ; haplamine ; cytotoxicity ; Haplophyllum spp
[en] An efficient system for the analysis of total alkaloids extracted from the aerial parts from different species of genus Hoplophyllum (Rutaceac) by HPLC on a reversed-phase column is described. The HIPLC method described was validated for its specificity, linearity and precision using external standards (haplopine, skimmianine and haplamine). The chromatographic conditions allowed the separation of alkaloids and the quantification of haplopine, skimmianine and haplamine in different samples of species of Haplophyllum collected in Uzbekistan. The alkaloidal contents of samples were compared with their in vitro cytotoxic properties against two cancer cell lines (HeLa. and HCT-116). The cytotoxicity of extracts was correlated with the concentration of haplopine, skimmianine or haplamine in aerial parts of species of Haplophyllum. Copyright (c) 2006 John Wiley
Researchers ; Professionals
http://hdl.handle.net/2268/5546

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