[en] The preparation of 75Se-ebselen (75Se-PZ 51) in a high radiochemica] yield (~40 %) and with a specific act'ivity of 240 mCi/mM (8.9 GBq/mM) is described.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Chemistry
Author, co-author :
Cantineau, Robert
Tihange, Guy
Plenevaux, Alain ; Université de Liège - ULiège > Centre de recherches du cyclotron
Christiaens, Léon
Guillaume, Marcel
Welter, A.
Dereu, N.
Language :
English
Title :
Synthesis of 75Se-2-phenyl-1,2-benzisoselenazol-3-(2H)-one (PZ 51; EBSELEN*). A novel biologically active organo-selenium compound
Publication date :
1986
Journal title :
Journal of Labelled Compounds and Radiopharmaceuticals
ISSN :
0362-4803
eISSN :
1099-1344
Publisher :
John Wiley & Sons Ltd.
Volume :
23
Issue :
1
Pages :
59-65
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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Müller A., Gabriel H., Sies H., Biochem. Pharmacol.; 1985.
Müller A., Cadenas E., Graf P., Sies H. (1984) A novel biologically active seleno-organic compound—1. Biochemical Pharmacology 33:3235.
Klaymann D.L., Griffin T.S. (1973) Reaction of selenium with sodium borohydride in protic solvents. A Facile Method for the introduction of selenium into organic molecules. Journal of the American Chemical Society 95:197.
