Article (Scientific journals)
Fluorinated analogs of nucleosides and fluorinated tracers of gene expression for positron emission tomography
Couturier, Olivier; Chatal, Jean-François; Hustinx, Roland
2004In Bulletin du Cancer, 91 (9), p. 695-703
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Keywords :
positron emission tomography; gene expression; fluorinated analogs of nucleosides
Abstract :
[en] F-18-FDG is currently the only fluorinated tracer used in routine clinical positron emission tomography (PET). Fluorine 18 is considered as the ideal radioisotope for PET, thanks to a low positron energy, which not only limits the dose rate to the patients but also provides high-resolution images. Furthermore, the 110 min. physical half-life allows for high-yield radiosynthesis, transport from the production site to the imaging site, and imaging protocols that could span hours, which permits dynamic studies and assessing metabolic processes that may be fairly slow Recently, synthesis of fluorinated tracers from prosthetic group precursors, which allows easier radiolabeling of biomolecules, has given a boost to the development of numerous fluorinated tracers, Given the wide availability of fluorine 18, such tracers may well develop into important routine tracers. This article is a review of the literature concerning fluorinated analogs of nucleosides and fluorinated radiotracers of gene expression recently developed and under investigation.
Disciplines :
Oncology
Radiology, nuclear medicine & imaging
Author, co-author :
Couturier, Olivier;  Hôtel-Dieu (Nantes) > Service de médecine nucléaire
Chatal, Jean-François;  Hôtel-Dieu (Nantes) > Service de médecine nucléaire
Hustinx, Roland  ;  Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire
Language :
English
Title :
Fluorinated analogs of nucleosides and fluorinated tracers of gene expression for positron emission tomography
Publication date :
September 2004
Journal title :
Bulletin du Cancer
ISSN :
0007-4551
eISSN :
1769-6917
Publisher :
John Libbey Eurotext Ltd, Montrouge, France
Volume :
91
Issue :
9
Pages :
695-703
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 February 2009

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