Reference : Functional amphiphilic and biodegradable copolymers for intravenous vectorization
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/5513
Functional amphiphilic and biodegradable copolymers for intravenous vectorization
English
Van Butsele, Kathy [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Robert mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
13-Dec-2007
Polymer
Elsevier Science
48
7431-7443
Yes (verified by ORBi)
International
0032-3861
Oxford
United Kingdom
[en] biomaterial ; nanomedicine ; review
[en] This paper aims at reporting on the design of polymeric drug nanocarriers used in cancer therapy, with a special emphasis on the control of their biodistribution. First, the prominent role of poly(ethylene oxide) in the lifetime of nanocarriers circulating in the blood stream is highlighted, and the origin of a passive targeting based on a difference in the anatomy of tumors and normal tissues is discussed. The main body of the review is devoted to the targeting of nanocarriers towards tumors and the underlying concepts. As a rule, either the constitutive polymer is stimuli-responsive and the locus of drug release is where the stimulation occurs, or a ligand endowed with specific recognition is grafted onto the nanocarrier. Finally, the fate of the nanocarrier after drug delivery and the bioelimination of the polymer(s) involved are briefly considered.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers
http://hdl.handle.net/2268/5513
10.1016/j.polymer.2007.09.048
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TXW-4PTW4TJ-5-1&_cdi=5601&_user=532038&_orig=browse&_coverDate=12%2F13%2F2007&_sk=999519973&view=c&wchp=dGLbVzz-zSkzS&md5=804c4537c627bfca88406266abcf18fb&ie=/sdarticle.pdf
http://www.elsevier.com/wps/find/journaldescription.cws_home/30466/description#description
The authors acknowledge Polymer (Elsevier) for allowing them to archive this paper.

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