Reference : AN APPROACH TO THE ASYMMETRIC-SYNTHESIS OF L-6-[F-18]FLUORODOPA VIA NCA NUCLEOPHILIC FLU...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/5512
AN APPROACH TO THE ASYMMETRIC-SYNTHESIS OF L-6-[F-18]FLUORODOPA VIA NCA NUCLEOPHILIC FLUORINATION
English
Lemaire, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Guillaume, Marcel [> > > >]
Cantineau, Robert [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Plenevaux, Alain mailto [> > > >]
Christiaens, Léon [> > > >]
1991
Applied Radiation & Isotopes
Pergamon Press
42
7
629-635
Yes (verified by ORBi)
International
0969-8043
Oxford
United Kingdom
[en] The NCA asymmetric synthesis of L-6-[F-18]fluorodopa starting from (1R,2R,5R)-[(+)-2-hydroxypinanyl-3-idene]glycine t-butyl ester as chiral agent has been developed. After F-18-fluorination of the two commercially available aldehydes either 6-nitroveratraldehyde or 6-nitropiperonal, the required alkylating [F-18]fluorobenzyl bromide derivative can be easily prepared by treatment with NaBH4 followed by SOBr2. Alkylation of the Schiff base was carried out with the lithium salt of 2,2,6,6-tetramethylpiperidine as base in anhydrous THF at -78-degrees-C. Following hydrolysis of the protecting groups with hydroxylamine and Hl, the L-amino acid was obtained in 75% L form (ee 50%) with a 10% decay corrected (120 min) radiochemical yield.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/5512

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