Reference : SYNTHESIS OF F-18 SUBSTITUTED AROMATIC-ALDEHYDES AND BENZYL BROMIDES, NEW INTERMEDIAT...
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/5508
SYNTHESIS OF F-18 SUBSTITUTED AROMATIC-ALDEHYDES AND BENZYL BROMIDES, NEW INTERMEDIATES FOR NCA [F-18] FLUORINATION
English
Lemaire, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Damhaut, Philippe [> > > >]
Plenevaux, Alain mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Cantineau, Robert [> > > >]
Christiaens, Léon [> > > >]
Guillaume, Marcel [> > > >]
1992
Applied Radiation & Isotopes
Pergamon Press
43
4
485-494
Yes (verified by ORBi)
International
0969-8043
Oxford
United Kingdom
[en] The synthesis of various [F-18]fluoroaromatic aldehydes using activated nitro precursors and aminopolyether supported nucleophilic substitution with F-18(-) is reported. These radiolabelled fluorinated aldehydes (radiochemical yields: 50-75%) are powerful key intermediates leading after treatment with NaBH4 and SOBr2 (SOCl2) to further active intermediates for example substituted [F-18]fluorobenzyl bromides (yields 30-50% EOB). These benzaldehydes and bromides are particularly useful for the preparation of new radiopharmaceuticals (e.g. fluorotroprapride, fluorodexetimide) either by reductive amination or by aromatic N-alkylation. The preparation of various amino acids in D, L (50:50) or enriched L form by asymmetric synthesis is also possible (e.g. L-6-[F-18]fluorodopa, L-4-[F-18]fluoro-m-tyrosine). It can be anticipated that the F-18-labelled fluoroaldehydes will find widespread application in radiopharmaceutical chemistry.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/5508

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