Reference : Improved performances of intraocular lenses by poly(ethylene glycol) chemical coatings
Scientific journals : Article
Engineering, computing & technology : Materials science & engineering
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/5507
Improved performances of intraocular lenses by poly(ethylene glycol) chemical coatings
English
Bozukova, Dimitriya [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Pagnoulle, Christophe [Physiol SA, Liège, Belgium > > > >]
Gillet, Marie-Claire mailto [University of Liège (ULg) > Département des sciences biomédicales et précliniques > Laboratory of Histology and Cytology > >]
Desbief, Simon [University of Mons-Hainaut (UMH) > > Chemistry of New Materials Department > >]
Lazzaroni, Roberto [University of Mons-Hainaut (UMH) > > Chemistry of New Materials Department > >]
Ruth, Nadia mailto [University of Liège (ULg) > > Center for Protein Engineering (CIP) > >]
Jérôme, Robert mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Aug-2007
Biomacromolecules
American Chemical Society
8
8
2379-2387
Yes (verified by ORBi)
International
1525-7797
1526-4602
Washington
DC
[en] biomaterial ; coating ; intraocular lens ; antifouling polymer ; implant
[en] Cataract surgery is a routine ophthalmologic intervention resulting in replacement of the opacified natural lens by a polymeric intraocular lens (IOL). A main postoperative complication, as a result of protein adsorption and lens epithelial cell (LEC) adhesion, growth, and proliferation, is the secondary cataract, referred to as posterior capsular opacification (PCO). To avoid PCO formation, a poly(ethylene glycol) (PEG) chemical coating was created on the surface of hydrogel IOLs. Attenuated total reflectance Fourier transform infrared spectroscopy, “captive bubble” and “water droplet” contact angle measurements, and atomic force microscopy analyses proved the covalent grafting of the PEG chains on the IOL surface while keeping unchanged the optical properties of the initial material. A strong decrease of protein adsorption and cell adhesion depending on the molar mass of the grafted PEG (1100, 2000, and 5000 g/mol) was observed by performing the relevant in vitro tests with green fluorescent protein and LECs, respectively. Thus, the study provides a facile method for developing materials with nonfouling properties, particularly IOLs.
Center for Education and Research on Macromolecules (CERM)
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The Walloon Region in the frame of the First Europe (SURFOLIO) program ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy
Researchers
http://hdl.handle.net/2268/5507
10.1021/bm0701649
http://pubs.acs.org/doi/pdf/10.1021/bm0701649

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