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| Reference : SYNTHESIS OF NONACTIVATED F-18 FLUORINATED AROMATIC-COMPOUNDS THROUGH NUCLEOPHILIC-SUBST... |
| Scientific journals : Article | |||
| Physical, chemical, mathematical & earth Sciences : Chemistry Human health sciences : Radiology, nuclear medicine & imaging | |||
| http://hdl.handle.net/2268/5466 | |||
| SYNTHESIS OF NONACTIVATED F-18 FLUORINATED AROMATIC-COMPOUNDS THROUGH NUCLEOPHILIC-SUBSTITUTION AND DECARBOXYLATION REACTIONS | |
| English | |
Plenevaux, Alain  [Université de Liège - ULg > > Centre de recherches du cyclotron >] | |
| Lemaire, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >] | |
| Palmer, Anthtony J. [> > > >] | |
| Damhaut, Philippe [> > > >] | |
| Comar, Dominique [> > > >] | |
| 1992 | |
| Applied Radiation & Isotopes | |
| Pergamon Press | |
| 43 | |
| 8 | |
| 1035-1040 | |
| International | |
| 0969-8043 | |
| Oxford | |
| United Kingdom | |
| [en] The synthesis of no-carrier-added 3-[F-18]fluoroanisole, 2-[F-18]fluoroanisole, [F-18]fluorobenzene and 4-[F-18]fluoroveratrole are reported. The strategy consists of amino-polyether supported nucleophilic substitution with [F-18]F- on activated nitro aromatic aldehyde precursors followed by decarbonylation using Tris(triphenylphosphine) rhodium (I) chloride. The experimental parameters for this reaction have been studied and optimized with 2-[F-18]fluoro-4-methoxybenzaldehyde and then successfully applied to four other F-18-fluorinated aromatic aldehydes. The decarbonylation yields obtained were 84 +/- 5% (corrected for decay) within 15 min at 150-degrees-C in 1,4-dioxan. | |
| Centre de Recherches du Cyclotron - CRC | |
| Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS | |
| Researchers ; Professionals ; Students | |
| http://hdl.handle.net/2268/5466 |
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