Reference : Synthesis of amphiphilic copolymers of poly(ethylene oxide) and poly(epsilon-caprolacton...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/5449
Synthesis of amphiphilic copolymers of poly(ethylene oxide) and poly(epsilon-caprolactone) with different architectures, and their role in the preparation of stealthy nanoparticles
English
Rieger, Jutta [University of Liège (ULg) > Deparment of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Passirani, Catherine [University of Angers, France > > INSERM U646, Ingénierie de la Vectorisation Particulaire > >]
Benoît, Jean-Pierre [University of Angers, France > > INSERM U646, Ingénierie de la Vectorisation Particulaire > >]
Van Butsele, Kathy [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Robert mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
21-Jul-2006
Advanced Functional Materials
Wiley-V C H Verlag Gmbh
16
11
1506-1514
Yes (verified by ORBi)
International
1616-301X
Weinheim
[en] ring-opening polymerization (ROP) ; lactone ; epoxide
[fr] self-assembly in solution ; organic nanoparticle
[en] Well-defined copolymers of biocompatible poly(epsilon-caprolactone) (PCL) and poly(ethylene oxide) (PEO) are synthesized by two methods. Graft copolymers with a gradient structure are prepared by ring-opening copolymerization of epsilon-caprolactone (FCL) with a PEO macromonomer of the epsilon CL-type. The epsilon CL polymerization is initiated by a PEO macroinitiator to prepare diblock copolymers. These amphiphilic copolymers are used as stabilizers for biodegradable poly(DL-lactide) (PLA) nanoparticles prepared by a nanoprecipitation technique. The effect of the copolymer characteristic features (architecture, composition, and amount) on the nanoparticle formation and structure is investigated. The average size, size distribution, and stability of aqueous suspensions of the nanoparticles is measured by dynamic light scattering. For comparison, an amphiphilic random copolymer, poly(methyl methacrylate-co-methacrylic acid) (P(MMA-co-MA)), is synthesized. The stealthiness of the nanoparticles is analyzed in relation to the copolymer used as stabilizer. For this purpose, the activation of the complement system by nanoparticles is investigated in vitro using human serum. This activation is much less important whenever the nanoparticles are stabilized by a PEO-containing copolymer rather than by the P(MMA-co-MA) amphiphile. The graft copolymers with a gradient structure and the diblock copolymers with similar macromolecular characteristics (molecular weight and hydrophilicity) are compared on the basis of their capacity to coat PLA nanoparticles and to make them stealthy.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers
http://hdl.handle.net/2268/5449
10.1002/adfm.200500110
http://www3.interscience.wiley.com/cgi-bin/fulltext/112659398/PDFSTART

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