ORBi: Jérôme Christine - Surface modification of metallic cardiovascular stents by strongly adhering aliphatic polyester coatings

Reference : Surface modification of metallic cardiovascular stents by strongly adhering aliphatic po...


	Document type :	Scientific journals : Article
	Discipline(s) :	Engineering, computing & technology : Materials science & engineering Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/5446

Title :	Surface modification of metallic cardiovascular stents by strongly adhering aliphatic polyester coatings
Language :	English
Author, co-author :	Jérôme, Christine [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Aqil, Abdelhafid [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Voccia, Samuel [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Labaye, David-Emmanuel [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Maquet, Véronique [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Gautier, Sandrine [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Bertrand, Olivier F [Qebec Heart-Lung Institute, Laval Hospital, Quebec City, Canada > > > >]
	Jérôme, Robert [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Publication date :	1-Mar-2006
Journal title :	Journal of Biomedical Materials Research, Part A
Publisher :	Wiley Liss, Inc.
Volume :	76
Issue/season :	3
Pages :	521-529
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	1549-3296
City :	Hoboken
Keywords :	[en] electropolymerization ; electrografting ; ring-opening polymerization (ROP) ; lactone
Abstract :	[en] This article reports on a novel two-step strategy for the coating of cardiovascular stents by strongly adhering biocompatible and biodegradable aliphatic polyesters. First, a precoating of poly(ethylacrylate) (PEA) was electrografted onto the metallic substrate by cathodic reduction of the parent monomer in dimethylformamide (DMF). The electrodeposition of PEA, in a good solvent of it, was confirmed by both Infra-red and Raman spectroscopies. The pendant ester groups of PEA were then chemically reduced into aluminum alkoxides, able to initiate the ring-opening polymerization (ROP) of either D,L-lactide (LA) or epsilon-caprolactone (CL). Growth of biodegradable PLA or PCL coatings from the adhering precoating was confirmed by both Infra-red and Raman spectroscopies, and directly observed by scanning electron microscopy (SEM). This type of coating can act as an anchoring layer for the subsequent casting of drug-loaded polyester films allowing the controlled release of antiproliferative agents for the treatment of in-stent restenosis.
Research units :	Center for Education and Research on Macromolecules (CERM)
Funders :	Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/5446
DOI :	10.1002/jbm.a.30256
Other URL :	http://www3.interscience.wiley.com/cgi-bin/fulltext/112162528/PDFSTART

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Restricted access	Jérôme C 2006 J Biomed Mat Res Part A 521.pdf	No commentary	Publisher postprint	265.81 kB	Request copy

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