Article (Scientific journals)
Surface modification of metallic cardiovascular stents by strongly adhering aliphatic polyester coatings
Jérôme, Christine; Aqil, Abdelhafid; Voccia, Samuel et al.
2006In Journal of Biomedical Materials Research. Part A, 76 (3), p. 521-529
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Keywords :
electropolymerization; electrografting; ring-opening polymerization (ROP); lactone
Abstract :
[en] This article reports on a novel two-step strategy for the coating of cardiovascular stents by strongly adhering biocompatible and biodegradable aliphatic polyesters. First, a precoating of poly(ethylacrylate) (PEA) was electrografted onto the metallic substrate by cathodic reduction of the parent monomer in dimethylformamide (DMF). The electrodeposition of PEA, in a good solvent of it, was confirmed by both Infra-red and Raman spectroscopies. The pendant ester groups of PEA were then chemically reduced into aluminum alkoxides, able to initiate the ring-opening polymerization (ROP) of either D,L-lactide (LA) or epsilon-caprolactone (CL). Growth of biodegradable PLA or PCL coatings from the adhering precoating was confirmed by both Infra-red and Raman spectroscopies, and directly observed by scanning electron microscopy (SEM). This type of coating can act as an anchoring layer for the subsequent casting of drug-loaded polyester films allowing the controlled release of antiproliferative agents for the treatment of in-stent restenosis.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Materials science & engineering
Chemistry
Author, co-author :
Jérôme, Christine  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Aqil, Abdelhafid ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Voccia, Samuel;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Labaye, David-Emmanuel;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Maquet, Véronique;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Gautier, Sandrine;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Bertrand, Olivier F;  Qebec Heart-Lung Institute, Laval Hospital, Quebec City, Canada
Jérôme, Robert ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Surface modification of metallic cardiovascular stents by strongly adhering aliphatic polyester coatings
Publication date :
01 March 2006
Journal title :
Journal of Biomedical Materials Research. Part A
ISSN :
1549-3296
eISSN :
1552-4965
Publisher :
Wiley Liss, Inc., Hoboken, United States - New Jersey
Volume :
76
Issue :
3
Pages :
521-529
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
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