Reference : Plasma concentration of insulin-like growth factor I (IGF-I) in growing Ardenner horses ...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/5418
Plasma concentration of insulin-like growth factor I (IGF-I) in growing Ardenner horses suffering from juvenile digital degenerative osteoarthropathy
English
Lejeune, Jean-Philippe mailto [Université de Liège - ULg et Centre européen du cheval de Mont-le-Soie > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux > > >]
Franck, Thierry mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Gangl, Monika [> > > >]
Schneider, Nicole mailto [Centre européen du cheval (Mont-le-Soie, Vielsalm) >]
Michaux, Charles mailto [Université de Liège - ULg > Département de productions animales > Biostatistique, économie, sélection animale >]
Deby-Dupont, Ginette [> > > >]
Serteyn, Didier mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Feb-2007
Veterinary Research Communications
Springer
31
2
185-195
Yes (verified by ORBi)
International
0165-7380
Dordrecht
[en] Ardenner ; horse ; IGF-I ; joint disease ; metabolism
[en] Degenerative osteoarthropathy resulting in a reduced active lifespan was observed in Ardenner horses. In the context of joint biology, insulin-like growth factor I (IGF-I) is a potential candidate to affect the anabolism of cartilage matrix molecules. A group of 30 Ardenner horses reared under standardized conditions from weaning were evaluated periodically from 15 to 28 months of age to detect the early manifestations of the disease. At the end of this period, horses were classified in two pathological groups related to the degree of interphalangeal degenerative osteoarthropathy based on clinical and radiographic evaluations: healthy (46.7%) and pathological (53.3%) horses. Seven sequential blood samples were taken from each horse (during the evaluation period) to study the variation of IGF-I plasma concentration. We tested the variations of the IGF-I plasma concentration during growth, and the effect of sex and of pathological classes. Significant variations were observed during the research period, with a maximum value corresponding to spring and a minimum in autumn. A significant reduction of the IGF-I plasma concentration was also observed in the pathological horses (433.5 +/- 19.5 ng/ml) compared to the healthy horses (493.9 +/- 18.2 ng/ml). An alteration in the level of this growth factor could induce a disregulation of the mechanisms involved in the local control of joint and bone tissue development.
Researchers ; Students
http://hdl.handle.net/2268/5418

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