Reference : Varicella-zoster virus latency in the adult rat is a useful model for human latent infec...
Scientific journals : Article
Human health sciences : Dermatology
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/5322
Varicella-zoster virus latency in the adult rat is a useful model for human latent infection
English
Sadzot-Delvaux, Catherine mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Virologie et immunologie - GIGA-M : Coordination scientifique >]
Debrus, Serge [ > > ]
Nikkels, Arjen mailto [Université de Liège - ULg > > Dermatologie >]
Piette, Jacques mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Virologie - Immunologie - Département des sciences de la vie - GIGA-Research >]
Rentier, Bernard mailto [Université de Liège - ULg > Services administratifs généraux > Recteur - GIGA-R : Virologie - Immunologie >]
1995
Neurology
Lippincott Williams & Wilkins
45
12, suppl. 8
S18-S20
Yes (verified by ORBi)
International
0028-3878
Philadelphia
[en] A model of latent infection by varicella-zoster virus (VZV) was obtained in the adult rat. Inoculation of VZV-infected cells in the skin led to infection of the peripheral nervous system. Latency was characterized by a long-lasting presence of the viral genome, of selected viral gene transcripts, and of at least one viral protein in the dorsal root ganglia. Reactivation has not been obtained in vivo, but has occurred ex vivo after repeated stresses. Many similarities with VZV latency in humans were found, making this model useful for vaccine and antiviral studies.
Researchers
http://hdl.handle.net/2268/5322

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