Varicella-zoster virus gene regulation

[en] The varicella-zoster virus genome contains 71 open reading frames (ORFs), five of which (ORF62, ORF4, ORF63, ORF61, and ORF10) encode regulatory proteins. ORF62 codes for the major immediate early protein of the virus exhibiting DNA-binding and regulatory functions. This protein, localized in the cell nucleus, is a functional homologue to ICP4 of herpes simplex virus type 1 (HSV-1). It trans-activates several varicella-zoster virus promoters of the various gene classes and autoregulates its own expression. ORF4 protein activates gene promoters provided they have basal activities, but it is not a functional homologue of HSV-1 ICP27. Gene regulation activity appears to be linked to its cysteine-rich C-terminal region. ORF63 codes for an immediate early protein mainly located in the cell nucleus. The regulatory functions it performs are still unclear. ORF61 protein is the functional homologue of HSV-1 ICPO. Its N-terminal region exhibits a RING domain responsible for trans-activating and trans-repressing activities. ORF10 protein exhibits similarities with HSV-1 VP16 and activates the ORF62 promoter.

Disciplines :

Immunology & infectious disease

Author, co-author :

Piette, Jacques ; Université de Liège - ULiège > Département des sciences de la vie - GIGA > Virologie - Immunologie

Defechereux, Patricia

Baudoux, Laurence

Debrus, Serge

Merville, Marie-Paule ; Université de Liège - ULiège > Sciences de la Vie > GIGA

Rentier, Bernard ; Université de Liège - ULiège > Département des Sciences de la Vie -GIGA > Virologie fondamentale et Immunologie

Language :

English

Title :

Varicella-zoster virus gene regulation

Publication date :

1995

Journal title :

Neurology

ISSN :

0028-3878

eISSN :

1526-632X

Publisher :

Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania

Volume :

Issue :

12, suppl. 8

Pages :

S23-S27

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 01 February 2009

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