Reference : Fast F-18 FDG synthesis by alkaline hydrolysis on a low polarity solid phase supports
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/5255
Fast F-18 FDG synthesis by alkaline hydrolysis on a low polarity solid phase supports
English
Lemaire, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Damhaut, P. [> > > >]
Lauricella, Benjamino mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Mosdzianowski, C. [> > > >]
Morelle, J. L. [> > > >]
Monclus, M. [> > > >]
Van Naemen, J. [> > > >]
Mulleneers, E. [> > > >]
Aerts, Joël mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Plenevaux, Alain mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Brihaye, C. [> > > >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
2002
Journal of Labelled Compounds & Radiopharmaceuticals
John Wiley & Sons
45
5
435-447
Yes
International
0362-4803
[en] [18F]FDG ; solid phase extraction ; hydrolysis ; ClDG ; fluorine ; [18F]FDM
[en] The synthesis of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) has been simplified by the use of a tC18 Sep Pak cartridge to effect purification and hydrolysis of the tetraacetylated [18F]fluoro-glucose compound ([18F]TAG). After radiolabelling, this derivative was trapped on a solid phase extraction (SPE) cartridge and the residual reaction solvent (CH3CN), reagents (K222, K2CO3,) and by-products removed by washing the support with water. After this cleaning step, the acetyl groups were cleaved on the same tC18 column using 2N sodium hydroxide. This fast reaction proceeded near quantitatively (>98%) at room temperature in less than 2 min. The [18F]FDG was then recovered with a small amount of water, neutralized with a slight excess of 2N hydrochloric acid, buffered for pH with a citrate solution and finally purified on a neutral alumina oxide and a second tC18 column. After filtration, the radiochemical yield of this [18F]FDG isotonic solution after more than 100 production runs was found to be very reliable and reproducible (70±6% decay corrected). The synthesis time was about 22 min. Quality controls showed that the radiochemical purity was higher than 98% and in any case no [18F]FDM was detected. Only traces of 2-chloro-2-deoxy-glucose (ClDG) were found in the final sample (64±9 g/ batch of 16 ml). [18F]FDG specific activity averaged between 1 and 20 Ci/µmol (EOS). No evaporation and use of ion retardation resin (AG11A8) are required. Moreover, this new approach is suitable for complete remote operation using available single use medical components. Copyright © 2002 John Wiley
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/5255
10.1002/jlcr.572

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