Article (Scientific journals)
18f-Fdg Pet Imaging in Assessing Exudative Pleural Effusions
DUYSINX, Bernard; Larock, Marie-Paule; Nguyen, Delphine et al.
2006In Nuclear Medicine Communications, 27 (12), p. 971-6
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Keywords :
positron emission tomography; fluorodeoxyglucose; pleural effusion; cancer
Abstract :
[en] BACKGROUND: This study evaluates the accuracy of [F]fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging with semi-quantitative analysis for differentiating benign from malignant pleural exudates and for guiding the search for the primary tumour of pleural metastases. METHODS: Whole-body 18F-FDG PET was performed in 79 patients with exudative pleurisy. Standard uptake values were normalized for body weight, body surface area, lean body mass (SUVbw, SUVbsa, SUVlbm) with and without correction for blood glucose levels. Thoracoscopy was systematically performed to reveal pathological diagnosis. RESULTS: All SUVs were significantly higher in all malignant pleural diseases (n = 51) than in benign (n = 28) (P < 0.001). Moreover SUVs were greater in the pleural metastases from pulmonary primaries (n = 25) and in mesotheliomas (n = 8) than in extrathoracic primaries (n = 18) (P < 0.01) with no significant difference between lung cancers and mesotheliomas. Receiver operating curve (ROC) analysis between benign and malignant lesions showed areas under the curves that ranged from 0.803 (SUVbsa g) to 0.863 (SUVbw). The cut-off value for SUVbw which gave the best accuracy (82.3%) was 2.2. When comparing thoracic with extrathoracic primaries the highest accuracy (80.4%) was found for a cut-off value of 2.6. CONCLUSION: Semi-quantitative analysis of 18F-FDG PET imaging helps to differentiate malignant from benign pleural exudates and to distinguish between thoracic or extrathoracic primaries.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
DUYSINX, Bernard ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Larock, Marie-Paule ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
Nguyen, Delphine
Corhay, Jean-Louis ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Bury, Thierry ;  Université de Liège - ULiège > Département des sciences de la motricité > Physiologie humaine et physiologie de l'effort physique
Hustinx, Roland  ;  Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire
Louis, Renaud ;  Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Language :
English
Title :
18f-Fdg Pet Imaging in Assessing Exudative Pleural Effusions
Publication date :
December 2006
Journal title :
Nuclear Medicine Communications
ISSN :
0143-3636
Publisher :
Lippincott Williams & Wilkins, United States
Volume :
27
Issue :
12
Pages :
971-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 30 January 2009

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