Reference : Characterization of the neurotoxicity induced by the extract of Magnistipula butayei (Ch...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/5222
Characterization of the neurotoxicity induced by the extract of Magnistipula butayei (Chrysobalanaceae) in rat: Effects of a new natural convulsive agent
English
Karangwa, Charles [Université Nationale du Rwanda - UNR > Pharmacie > > >]
Esters, Virginie mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Tits, Monique mailto [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
Minet, Arlette mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Boland, André mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Seutin, Vincent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
Noirfalise, Alfred mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Grisar, Thierry mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique]
Foidart, Agnès mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Service administratif de la Faculté (Médecine) >]
15-Jun-2007
Toxicon
Pergamon-Elsevier Science Ltd
49
8
1109-1119
Yes (verified by ORBi)
International
0041-0101
Oxford
[en] Magtustipula ; convulsant ; neurotoxin ; seizure ; electroencephalography
[en] This study was designed to document convulsant and neurotoxic properties of extracts of a tropical tree, Magnistipula butayei subsp. Montana, and to investigate the involvement of the glutamatergic system in these effects. Continuous behavioral observations and electroencephalographic (EEG) records were obtained after per os administration of an aqueous extract of Magnistipula (MBMAE) in rats. MBMAE (800 mg/kg) induced behavioral changes resembling motor limbic seizures: staring and head tremor, automatisms, forelimb clonic movements and violent tonic-clonic seizures leading to death in all animals. Concomitantly, important seizure activity that gradually evolved to epileptiform activity was recorded on the EEG. Moreover, c-Fos immunohistochemistry has revealed an increased c-Fos expression in the dentate gyrus and in piriform, peri- and entorhinal cortices 2 and 4h after treatment. This expression pattern suggested that the mechanism of action for the MBMAE is similar to that observed in glutamate-induced models of epilepsy. The MBMAE increased cell death also in hippocampal cell cultures. Furthermore, the build-up of convulsive activity and epileptic discharges induced by MBMAE in rat were abolished by MK-801, an NMDA receptor antagonist. Our study suggests that MBMAE contains a potent toxin, with a powerful neurotoxic activity in rat, and corresponding to a new natural component(s) that act as an NMDA-mediated convulsant molecule.
Centre Interfacultaire de Recherche du Médicament (C.I.R.M.)
Researchers ; Professionals
http://hdl.handle.net/2268/5222
10.1016/j.toxicon.2007.02.001

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