Reference : Mismatch negativity is not correlated with neuroendocrine indicators of catecholaminergi...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/5221
Mismatch negativity is not correlated with neuroendocrine indicators of catecholaminergic activity in healthy subjects.
English
Hansenne, Michel mailto [Université de Liège - ULg > Département des sciences cognitives > Psycho. de la personnalité et des différences individuelles >]
Pinto, Emmanuel mailto [Centre Hospitalier Universitaire de Liège - CHU > > Psychiatrie et psychologie médicale >]
Scantamburlo, Gabrielle mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Couvreur, Anne [Centre Hospitalier Universitaire de Liège - CHU > > Psychiatrie et psychologie médicale >]
Reggers, Jean [Centre Hospitalier Universitaire de Liège - CHU > > HOSPITALISATION - PSYCHO & PSYCHIATRIE T3 -3E - Psychiatrie et psychologie médicale >]
Fuchs, Sonia [> > > >]
Pitchot, William mailto [Centre Hospitalier Universitaire de Liège - CHU > > Psychiatrie et psychologie médicale >]
Ansseau, Marc mailto [Centre Hospitalier Universitaire de Liège - CHU > > Psychiatrie et psychologie médicale >]
2003
Human Psychopharmacology
John Wiley & Sons, Inc
18
3
201-5
Yes (verified by ORBi)
0885-6222
1099-1077
West Sussex
United Kingdom
[en] Acoustic Stimulation/methods ; Adult ; Apomorphine/diagnostic use ; Brain/physiology ; Clonidine/diagnostic use ; Contingent Negative Variation/physiology ; Dopamine/metabolism ; Evoked Potentials, Auditory/physiology ; Female ; Human Growth Hormone/blood ; Humans ; Male ; Norepinephrine/metabolism
[en] The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of the mismatch negativity (MMN) may contribute to a clearer understanding of its functional significance, and may have clinical implications. In this context, some findings suggest that the scalp-recorded MMN reflects activity from multiple neuronal ensembles within or in the immediate vicinity of the primary auditory cortex and with possible contribution from the frontal cortex. However, few data are available concerning the influence of neurotransmitter systems on the MMN. In this study, the relationship between both noradrenergic and dopaminergic systems and the MMN were investigated in 34 healthy volunteers. Noradrenergic and dopaminergic activities were assessed with the apomorphine and clonidine challenge tests. The results showed no significant relationship between either growth hormone (GH) responses to apomorphine or clonidine and the MMN amplitude or latency. Therefore, this study does not demonstrate the implication of dopaminergic and noradrenergic activities as assessed by GH response to apomorphine and clonidine for the generation and/or the modulation of the MMN. However, given the complexity of the central neurotransmitter systems, these results cannot be considered as definitive evidence against a relationship between dopaminergic and noradrenergic activity and the MMN.
Centre de Neurosciences Comportementale et Cognitive
http://hdl.handle.net/2268/5221
10.1002/hup.468
Copyright 2002 John Wiley & Sons, Ltd.

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