Article (Scientific journals)
Prolonged anhepatic state after early liver graft removal
Detry, Olivier; De Roover, Arnaud; Delwaide, Jean et al.
2007In Hepato-Gastroenterology, 54 (79, Oct-Nov), p. 2109-2112
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Keywords :
liver failure; liver transplantation; liver support; brain; brain edema; intracranial pressure
Abstract :
[en] Two-stage liver transplantation, i.e. salvage emergent total hepatectomy with prolonged anhepatic state, and subsequent liver transplantation, has been described as a life-saving procedure in selected cases. The principal drawback of two-stage liver transplantation is the fact that anhepatic patient survival only depends on the future availability of a liver graft. The pathophysiologic alterations induced by total hepatectomy are not fully known, as it is not known how long a patient may be anhepatic before it is too late for hope of survival. In this report the authors describe the cases of three liver recipients who had to undergo salvage liver graft removal early during or after liver transplantation as a life-saving maneuver. All were afterwards registered for emergent liver retransplantation. Mean anhepatic period was 20 hours (Range: 17-24 hours). Two patients survived and fully recovered. From this experience and from other cases reported in the literature, the authors concluded that total hepatectomy may be life-saving in some cases if a liver graft is available in a timely manner.
Disciplines :
Surgery
Author, co-author :
Detry, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
De Roover, Arnaud ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Delwaide, Jean ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Hans, Marie-France ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Canivet, Jean-Luc ;  Centre Hospitalier Universitaire de Liège - CHU > Soins intensifs
Meurisse, Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Chirurgicale abdominale
Honore, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Language :
English
Title :
Prolonged anhepatic state after early liver graft removal
Publication date :
2007
Journal title :
Hepato-Gastroenterology
ISSN :
0172-6390
Publisher :
H G E Update Medical Publishing S A, Athens, Greece
Volume :
54
Issue :
79, Oct-Nov
Pages :
2109-2112
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 August 2008

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