Reference : Discovery of a natural thiamine adenine nucleotide
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/518
Discovery of a natural thiamine adenine nucleotide
English
Bettendorff, Lucien mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
Wirtzfeld, Barbara [> > > >]
Makarchikov, Alexander F [> > > >]
Mazzucchelli, Gabriel mailto [Université de Liège - ULg > > Centre interfac. d'analyse des résidus en traces (CART) >]
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Gigliobianco, Tiziana mailto [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. >]
Gangolf, Marjorie [Université de Liège - ULg > > Biochimie et physiologie humaine et pathologique >]
De Pauw, Edwin mailto [Université de Liège - ULg > > Chimie physique, spectrométrie de masse >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Wins, Pierre [> > > >]
2007
Nature Chemical Biology
Nature Publishing Group
3
4
211-212
Yes (verified by ORBi)
International
1552-4450
New York
[en] Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues.
http://hdl.handle.net/2268/518
10.1038/nchembio867

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