ORBi: Bettendorff Lucien - Discovery of a natural thiamine adenine nucleotide

Reference : Discovery of a natural thiamine adenine nucleotide


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/518
	Discipline :	Life sciences : Biochemistry, biophysics & molecular biology

Title :	Discovery of a natural thiamine adenine nucleotide
Language :	English
Author, co-author :	Bettendorff, Lucien [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
	Wirtzfeld, Barbara [> > > >]
	Makarchikov, Alexander F [> > > >]
	Mazzucchelli, Gabriel [Université de Liège - ULg > > Centre interfac. d'analyse des résidus en traces (CART) >]
	Frederich, Michel [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
	Gigliobianco, Tiziana [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. >]
	Gangolf, Marjorie [Université de Liège - ULg > > Biochimie et physiologie humaine et pathologique >]
	De Pauw, Edwin [Université de Liège - ULg > > Chimie physique, spectrométrie de masse >]
	Angenot, Luc [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
	Wins, Pierre [> > > >]
Publication date :	2007
Journal title :	Nature Chemical Biology
Publisher :	Nature Publishing Group
Volume :	3
Issue/season :	4
Pages :	211-212
Audience :	International
ISSN :	1552-4450
City :	New York
Abstract :	[en] Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues.
Permalink :	http://hdl.handle.net/2268/518
DOI :	10.1038/nchembio867

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