Reference : Myeloperoxidase Assay in Plasma and Peritoneal Fluid of Horses with Gastrointestinal Dis...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/5172
Myeloperoxidase Assay in Plasma and Peritoneal Fluid of Horses with Gastrointestinal Disease
English
Grulke, Sigrid mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés >]
Franck, Thierry mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Gangl, Monika [> > > >]
Péters, Fabrice [> >]
Salciccia, Alexandra mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés >]
Deby, Ginette [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Serteyn, Didier mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Jan-2008
Canadian Journal of Veterinary Research = Revue Canadienne de Recherche Vétérinaire
72
1
37-42
Yes (verified by ORBi)
International
0830-9000
Canada
[en] horse ; Colic ; myeloperoxidase
[fr] peritoneal fluid
[en] Gastrointestinal disorders, especially strangulating intestinal obstructions, are still a major cause of illness and death in the horse. Circulating lipopolysaccharides may activate both neutrophils and monocytes. The activated neutrophils release myeloperoxidase (MPO), a specific enzyme with strong oxidative activity. The aim of this study was to evaluate MPO concentrations in the plasma and peritoneal fluid (PF) of horses with colic and to check the hypothesis that these concentrations would be higher in a case of strangulating obstruction than in cases of nonstrangulating disease. By using a specific enzyme-linked immunosorbent assay for equine MPO, we determined the MPO concentrations in horses admitted to a clinic for colic. Horses with nonstrangulating or strangulating obstruction of the large intestine (NSLI or SLI), strangulating obstruction of the small intestine (SSI), or inflammatory bowel disease (IBD) were compared with healthy horses. The horses with SLI, SSI, or IBD had significantly higher MPO levels in plasma and PF than did those in the other 2 groups. The mean plasma level was significantly higher in the horses with NSLI than in the healthy horses. High MPO values in PF indicated necrotic bowel. These results show that neutrophil activation occurs during nonstrangulating and strangulating intestinal obstruction in horses and that the plasma and PF MPO concentrations may be a marker of the severity of the disease.
Centre de l'Oxygène, Recherche et Développement (CORD)
Researchers ; Professionals
http://hdl.handle.net/2268/5172

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