Reference : Phonological short-term memory networks following recovery from Landau and Kleffner synd...
Scientific journals : Article
Human health sciences : Neurology
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/5170
Phonological short-term memory networks following recovery from Landau and Kleffner syndrome
English
Majerus, Steve mailto [Université de Liège - ULg > Département des sciences cognitives > Psychopathologie cognitive >]
Laureys, Steven mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Collette, Fabienne mailto [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie >]
Del Fiore, Guy [> > > >]
Degueldre, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Van der Linden, Martial mailto [Université de Liège - ULg > Département des sciences cognitives > Psychopathologie cognitive >]
Maquet, Pierre mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Metz-Lutz, Marie-Noëlle [> > > >]
Jul-2003
Human Brain Mapping
Wiley Liss, Inc.
19
3
133-144
Yes (verified by ORBi)
International
1065-9471
New York
[en] verbal short-term memory ; PET ; Landau-Kleffner ; epilepsy ; aphasia
[fr] aphasie ; épilepsie ; imagerie cérébrale fonctionnelle ; mémoire à court terme ; syndrome de Landau-Kleffner
[en] Landau-Kleffner syndrome (LKS) is a rare acquired aphasia occurring in otherwise healthy children, together with spike-wave discharges predominating over superior temporal regions and activated by sleep. Although the outcome of language abilities is variable, a residual impairment in verbal short-term memory (STM) is frequent. This STM deficit might be related to the persistent dysfunction of those temporal lobe regions where epileptic discharges were observed during the active phase of the disorder. We tested this hypothesis by measuring brain activation during immediate serial recall of lists of 4 words, compared to single word repetition, using H(2) (15)O positron emission tomography (PET), in 3 LKS patients after recovery and in 14 healthy controls. The patients (TG, JPH, and DC) had shown abnormally increased or decreased glucose metabolism in left or right superior temporal gyrus (STG) at different stages during the active phase of their disease. At the time of this study, the patients were 6-10 years from the active phase of LKS. Results showed that Patients JPH and DC had impaired performance in the STM condition, whereas TG showed near normal performance. PET data showed that JPH and DC activated significantly less than controls left and right posterior STG. TG, having near normal STM performance, showed increased activity in the posterior part of the right STG. These data suggest that impaired verbal STM at late outcome of LKS might indeed be related to a persistent decrease of activity in those posterior superior temporal gyri that were involved in the epileptic focus during the active phase.
http://hdl.handle.net/2268/5170
10.1002/hbm.10113

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