Chemical processing for production of no-carrier-added selenium-73 from germanium and arsenic targets and synthesis of L-2-amino-4-([73Se]methylseleno) butyric acid (L-[73Se]selenomethionine).
[en] The Ge(4He, xn) and 75As(p, 3n) reactions were compared as the best potential routes for routine production of selenium-73 (73Se) for medical applications. With 26 MeV alpha particles, available with compact cyclotrons, the first reaction required an enriched 70Ge target of sodium metagermanate to give a production yield of 1 mCi/microAh (0.037 GBq/microAh) in a 105 mg/cm2 target. With 55 MeV protons the As(p, 3n) reaction on natural arsenic yielded 20 mCi/microAh (0.74 GBq/microAh) in a 685 mg/cm2 target. A simple method was developed and optimized for both targets in order to isolate and purify the no-carrier-added selenium in the elemental form with a radiochemical yield greater than 75% in less than 90 min. An automated radiochemical processing unit has been designed for the routine production of 100-150 mCi (3.7-5.5 GBq) batches of carrier-free 73Se ready for radiopharmaceutical labeling. 30 mCi (1.11 GBq) (EOS) of L-2-amino-4-([73Se]methylseleno) butyric acid (L-[73Se]selenomethionine) ready for injection with a specific activity of 5 Ci/mmol (185 GBq/mmol) (EOS) were obtained through a fast chemical synthesis. Radiation absorbed dose estimates for L-[73Se]selenomethionine have been determined. A value of 0.70 rem/mCi (0.19 mSv/MBq) administered was calculated for the risk from irradiation in man. The first human PET investigation with [73Se]selenomethionine showed a very good delineation between liver and pancreas.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Plenevaux, Alain ; Université de Liège - ULiège > Centre de recherches du cyclotron
Guillaume, Marcel
Brihaye, Claude
Lemaire, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron
Cantineau, Robert
Language :
English
Title :
Chemical processing for production of no-carrier-added selenium-73 from germanium and arsenic targets and synthesis of L-2-amino-4-([73Se]methylseleno) butyric acid (L-[73Se]selenomethionine).
Publication date :
1990
Journal title :
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
ISSN :
0883-2889
Publisher :
Pergamon Press, Oxford, United Kingdom
Volume :
41
Issue :
9
Pages :
829-38
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Agnew, Maze, Mitchell (1976) Pancreas scanning. Br. J. Radiol. 49:979.
Blau, Bender (1962) 75Se-selenomethionine for visualization of the pancreas by isotope scanning. Radiology 78:974.
Cloutier, Watson, Rohrer, Smith (1973) Calculating the radiation dose to an organ. J Nucl Med 14:53.
Coffey, Cristy, Warner (1981) Specific absorbed fractions for photon sources uniformly distributed in the heart chamber and the heart wall of a heterogeneous phantom. J. Nucl. Med. 22:65.
Conti, Hégésippe, De Saint-Sauveur, Tempé (1972) Biosynthèse de sélénomethionine 75Se pour usage scintigraphique. Int. J. Appl. Radiat. Isot. 23:415.
Eckerman, Cristy, Warner (1980) Dosimetric evaluation of brain scanning agents. Proc. 3rd Int. Radiopharmaceutical Dosimetry Symp. , E.E. Watson, A.T. Schlafke-Stelson, J.L. Coffey, R.J. Cloutier, Oak Ridge, 7–10 Oct. 1980, HHS publication, FDA 81-8166, U.S. Department of Health and Human Services, Rockville, Md, U.S.A; 527-540.
Guillaume, Lambrecht, Wolf (1978) Cyclotron isotopes and radiopharmaceuticals-XXVII. 73Se. Int. J. Appl. Radiat. Isot. 29:411.
Hara, Tilbury, Freed, Woodard, Laughlin (1973) Production of 73Se and its uptake in tumors of mice. Int. J. Appl. Radiat. Isot. 24:377.
ICRP Recommendations of the International Commission on Radiological Protection , Publication; 1977, 26:21.
Kocher Radioactive Decay Data Tables, J.S. Smith, Technical Information Center, U.S. DOE, Springfield, Va, U.S.A; 1981.
Lathrop, Johnston, Blau, Rothschild (1972) Radiation dose to humans from 75Se-l-selenomethionine. J. Nucl. Med. , (Suppl. 6), Pamphlet No. 10; 13:10.
Loevinger, Berman A Revised Scheme for Calculating the Absorbed Dose from Biologically Distributed Radionuclides, Society of Nuclear Medicine, New York, MIRD Pamphlet No. 1 (revised); 1976.
Mushtaq, Quaim, Stöcklin (1988) Production of 73Se via (p, 3n) and (d, 4n) reactions on arsenic. Appl. Radiat. Isot. 39:1085.
Nägren, Långström (1988) Synthesis of d/l- and l-Se-[methyl-11C]selenomethionine. Journal of Labelled Compounds and Radiopharmaceuticals 25:133.
Nozaki, Itoh, Ogawa (1979) Yield of 73Se for various reactions and its chemical processing. Int. J. Appl. Radiat. Isot. 30:595.
Plenevaux, Cantineau, Guillaume, Christiaens, Tihange (1987) Fast chemical synthesis of [75Se]l-selenomethionine. Appl. Radiat. Isot. 38:59.
Pugh (1926) Salts of germanic acid. J. Chem. Soc. (London) 2828.
Snyder, Ford, Warner Estimates of Specific Absorbed Fractions for Photon Sources Uniformly Distributed in Various Organs of a Heterogeneous Phantom, Society of Nuclear Medicine, New York, MIRD Pamphlet No. 5 (revised); 1978.
Sodee (1964) Radioisotopes scanning of the pancreas with [75Se]selenomethionine. Medical Radioisotope Scanning , IAEA, Vienna; 2:289.
Williamson, Boujot, Picard (1966) Tables of Range and Stopping Power of Chemical Elements for Charged Particles of Energy 0.5 to 500 MeV. Report CEA-R-3042, Commissariat à l'Energie Atomique, Paris; .
