Article (Scientific journals)
Shaker-type potassium channel subunits differentially control oligodendrocyte progenitor proliferation
Vautier, Francois; Belachew, Shibeshih; Chittajallu, Ramesh et al.
2004In Glia, 48 (4), p. 337-345
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Keywords :
oligodendrocyte precursor cells; K+ channels; Kv1 subunits; mitogens
Abstract :
[en] Oligodendrocyte precursor (OP) cells are exposed to multiple extrinsic signals that control their proliferation and differentiation. Previous cell proliferation studies and electrophysiological analysis in cultured cells and in brain slices have suggested that outward potassium channels, particularly Kv1 subunits, may have a prominent role in OP cell proliferation. In the present study, we assessed to what extent overexpression of Kv1.3, Kv1.4, Kv1.5, and Kv1.6 can affect OP cell proliferation and differentiation in culture. We observed that overexpression of Kv1.3 or Kv1.4 increased OP cell proliferation in the absence of mitogens, whereas Kv1.6 overexpression inhibited mitogen-induced OP cell cycle progression. Interestingly, Kv1.3, Kv1.4, Kv1.5, and Kv1.6 overexpression did not interfere with the kinetics of oligodendrocyte differentiation. This study represents the first demonstration that the activity of potassium channels containing distinct Kv1 subunit proteins directly controls oligodendroglial proliferation in the presence of mitogens, as well as in growth factor-free conditions. (C) 2004 Wiley-Liss, Inc.
Disciplines :
Neurosciences & behavior
Author, co-author :
Vautier, Francois;  NIH, Besthesda > NICHD > LCSN
Belachew, Shibeshih ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Chittajallu, Ramesh;  NIH, Besthesda > NICHD > LCSN
Gallo, Vittorio;  NIH, Besthesda > NICHD > LCSN
Language :
English
Title :
Shaker-type potassium channel subunits differentially control oligodendrocyte progenitor proliferation
Publication date :
December 2004
Journal title :
Glia
ISSN :
0894-1491
eISSN :
1098-1136
Publisher :
Wiley Liss, Inc., Hoboken, United States - New Jersey
Volume :
48
Issue :
4
Pages :
337-345
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 January 2009

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