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| Reference : Mannosylated poly(ethylene oxide)-b-Poly(epsilon-caprolactone) diblock copolymers: Synth... |
| Scientific journals : Article | |||
| Engineering, computing & technology : Materials science & engineering Physical, chemical, mathematical & earth Sciences : Chemistry | |||
| http://hdl.handle.net/2268/5015 | |||
| Mannosylated poly(ethylene oxide)-b-Poly(epsilon-caprolactone) diblock copolymers: Synthesis, characterization, and interaction with a bacterial lectin | |
| English | |
| Rieger, Jutta [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >] | |
| Stoffelbach, François [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >] | |
| Cui, Di [Université Joseph Fourier and the Institut de Chimie Moléculaire de Grenoble, France > > Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS) > >] | |
| Imberty, Anne [Université Joseph Fourier and the Institut de Chimie Moléculaire de Grenoble, France > > Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS) > >] | |
| Lameignere, E. [Université Joseph Fourier and the Institut de Chimie Moléculaire de Grenoble, France > > Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS) > >] | |
| Putaux, Jean-Luc [Université Joseph Fourier and the Institut de Chimie Moléculaire de Grenoble, France > > Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS) > >] | |
Jérôme, Robert  [Université de Liège - ULg > > Centre d'études et de rech. sur les macromolécules (CERM) >] | |
| Jérôme, Christine [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >] | |
| Auzely-Velty, Rachel [Université Joseph Fourier and the Institut de Chimie Moléculaire de Grenoble, France > > Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS) > >] | |
| Sep-2007 | |
| Biomacromolecules | |
| Amer Chemical Soc | |
| 8 | |
| 9 | |
| 2717-2725 | |
| International | |
| 1525-7797 | |
| Washington | |
| [en] ring-opening polymerization (ROP) ; lactone ; epoxide ; self-assembly in solution ; micelle ; biomaterial | |
| [fr] nanomedicine | |
| [en] A novel bioeliminable amphiphilic poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PEO-b-PCL) diblock copolymer end-capped by a mannose residue was synthesized by sequential controlled polymerization of ethylene oxide and epsilon-caprolactone, followed by the coupling of a reactive mannose derivative to the PEO chain end. The anionic polymerization of ethylene oxide was first initiated by potassium 2-dimethylaminoethanolate. The ring-opening polymerization of epsilon-caprolactone was then initiated by the omega-hydroxy end-group of PEO previously converted into an Al alkoxide. Finally, the saccharidic end-group was attached by quaternization of the tertiary amine (alpha-end-group of the PEO-b-PCL with a brominated mannose derivative. The copolymer was fully characterized in terms of chemical composition and purity by high-resolution NMR spectroscopy and size exclusion chromatography. Furthermore, measurements with a pendant drop tensiometer showed that both the mannosylated copolymer and the non-mannosylated counterpart significantly decreased the dichloromethane/water interfacial tension. Moreover, these amphiphilic copolymers formed monodisperse spherical micelles in water with an average diameter of similar to 11 nin as measured by dynamic light scattering and cryo-transmission electron microscopy. The availability of mannose as a specific recognition site at the surface of the micelles was proved by isothermal titration microcalorimetry (ITC), using the BclA lectin (from Burkholderia cenocepacia), which interacts selectively with a-D-mannopyranoside derivatives. The thermodynamic parameters of the lectin/mannose interaction were extracted from the ITC data. These colloidal systems have great potential for drug targeting and vaccine delivery systems. | |
| Center for Education and Research on Macromolecules (CERM) | |
| Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Marie Curie fellowship (for Jutta Rieger) ; The MENRT ; the FNRS for a grant in the frame of the “SONS-EUROCORES” program | |
| Researchers | |
| http://hdl.handle.net/2268/5015 | |
| 10.1021/bm070342y | |
| http://pubs.acs.org/doi/pdf/10.1021/bm070342y |
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