Reference : A review of the literature on neuroimaging of serotoninergic function in Alzheimer's ...
Scientific journals : Letter to the editor
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
http://hdl.handle.net/2268/5004
A review of the literature on neuroimaging of serotoninergic function in Alzheimer's disease and related disorders
English
Salmon, Eric mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Sep-2007
Journal of Neural Transmission
Springer Wien
114
9
1179-1185
Yes (verified by ORBi)
International
0300-9564
Wien
[en] serotonin ; functional imaging ; Alzheimer ; frontotemporal dementia
[en] Behavioural and psychological disorders are frequent not only in frontotemporal dementia (FTD), but also in Alzheimer's disease (AD), and many of them are related to serotoninergic dysfunction. In vitro biochemical measurements on brain samples show both pre- and post-synaptic impaired brain serotoninergic function in degenerative dementia, sometimes related to hyperactivity or aggressive behaviour. To date, few studies have explored in vivo 5HT2A and 5HT1A brain receptors in AD and FTD. They suggest that brain cells are lost in the associative cortices (5HT2A) and hippocampus (5HT1A) of AD patients, and in the medial prefrontal and orbitofrontal cortices of FTD subjects (5HT2A). Apart from reflecting a loss of local neurons, the meaning of the decrease in 5HT receptors is not yet clear and larger populations are required to establish relationships with clinical symptoms such as dementia severity and search for possible consequences for patients' behavioural and affective status.
European program DIMI
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
http://hdl.handle.net/2268/5004
http://www.springerlink.com/content/r58164r8t977/?sortorder=asc&p_o=10

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