Article (Scientific journals)
Metabolic correlates of clinical heterogeneity in questionable Alzheimer’s disease
Salmon, Eric; Lekeu, Françoise; Garraux, Gaëtan et al.
2008In Neurobiology of Aging, 29, p. 1823-1829
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Keywords :
Mild cognitive impairment; MCI; Alzheimer; Functional imaging; PET
Abstract :
[en] Thirty-four subjects with questionable Alzheimer's disease (QAD) were included in a 3-year prospective study and underwent neuropsychological testing and measurement of brain metabolism using FDG-PET at entry. Seventeen patients (50%) did not convert to AD during the follow-up period. Compared to elderly controls of similar age, the cerebral activity of non-converters was reduced in the dorsolateral prefrontal cortex. Moreover, the variability of metabolism in the posterior cingulate cortex was related to their visuospatial memory performance, while disparity in parietal activity was related to their verbal memory performance. These results demonstrate the cerebral metabolic heterogeneity of patients with QAD. Initial functional images of converters showed that activity was already impaired in the posterior cingulate, lateral temporal cortex, anterior cingulate and orbitofrontal cortex. This metabolic pattern is consistent with a pre-dementia stage of AD, and highlights the fact that significant frontal metabolic involvement may be associated with impaired activity in posterior associative cortices in very early AD.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Neurosciences & behavior
Author, co-author :
Salmon, Eric  ;  Université de Liège - ULiège > Centre de Recherches du Cyclotron > Département des sciences cliniques: Neuroimagerie des troubles de la mémoire et révalid. cogn.
Lekeu, Françoise ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman - Gériatrie
Garraux, Gaëtan  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Guillaume, Bénédicte ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Magis, Delphine ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Moonen, Gustave  ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Collette, Fabienne  ;  Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie - Département des sciences cognitives
Language :
English
Title :
Metabolic correlates of clinical heterogeneity in questionable Alzheimer’s disease
Publication date :
2008
Journal title :
Neurobiology of Aging
ISSN :
0197-4580
eISSN :
1558-1497
Publisher :
Elsevier, New York, United States - New York
Volume :
29
Pages :
1823-1829
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
European program NEST-DD
IUAP P5/04
Available on ORBi :
since 28 January 2009

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