Reference : Metabolic correlates of clinical heterogeneity in questionable Alzheimer’s disease
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
http://hdl.handle.net/2268/5002
Metabolic correlates of clinical heterogeneity in questionable Alzheimer’s disease
English
Salmon, Eric mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron > Département des sciences cliniques: Neuroimagerie des troubles de la mémoire et révalid. cogn. > > >]
Lekeu, Françoise [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman - Gériatrie >]
Garraux, Gaëtan mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Guillaume, Bénédicte [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Magis, Delphine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Moonen, Gustave mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Collette, Fabienne mailto [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie - Département des sciences cognitives >]
2008
Neurobiology of Aging
Elsevier
29
1823-1829
Yes (verified by ORBi)
International
0197-4580
1558-1497
New York
NY
[en] Mild cognitive impairment ; MCI ; Alzheimer
[fr] Functional imaging ; PET
[en] Thirty-four subjects with questionable Alzheimer's disease (QAD) were included in a 3-year prospective study and underwent neuropsychological testing and measurement of brain metabolism using FDG-PET at entry. Seventeen patients (50%) did not convert to AD during the follow-up period. Compared to elderly controls of similar age, the cerebral activity of non-converters was reduced in the dorsolateral prefrontal cortex. Moreover, the variability of metabolism in the posterior cingulate cortex was related to their visuospatial memory performance, while disparity in parietal activity was related to their verbal memory performance. These results demonstrate the cerebral metabolic heterogeneity of patients with QAD. Initial functional images of converters showed that activity was already impaired in the posterior cingulate, lateral temporal cortex, anterior cingulate and orbitofrontal cortex. This metabolic pattern is consistent with a pre-dementia stage of AD, and highlights the fact that significant frontal metabolic involvement may be associated with impaired activity in posterior associative cortices in very early AD.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; European program NEST-DD ; IUAP P5/04
Researchers ; Professionals
http://hdl.handle.net/2268/5002
also: http://hdl.handle.net/2268/11372
10.1016/j.neurobiolaging.2007.04.016
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T09-4NVSWNS-2&_user=532038&_coverDate=12%2F31%2F2008&_rdoc=8&_fmt=high&_orig=browse&_srch=doc-info(%23toc%234857%232008%23999709987%23700449%23FLA%23display%23Volume)&_cdi=4857&_sort=d&_docanchor=&_ct=20&_acct=C000026659&_version=1&_urlVersion=0&_userid=532038&md5=b51cf1becf46310cd0faa4da92f1e88b

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