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| Reference : The lipid phosphatase SHIP2 controls insulin sensitivity |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology Life sciences : Genetics & genetic processes | |||
| http://hdl.handle.net/2268/4960 | |||
| The lipid phosphatase SHIP2 controls insulin sensitivity | |
| English | |
| Clément, S. [IRIBHN, IBMM, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies > > > >] | |
| Krause, U. [ICP, Hormone and Metabolic Research Unit, Avenue Hippocrate 75, 1200 Brussels , Belgium > > > >] | |
| Desmedt, F. [INSERM E9911, Faculté de Médecine , Avenue de Valombrose, 06107 Nice, Cedex 02, France > > > >] | |
| Tanti, J. F. [University of Toronto, University Avenue 620, M5G 2C1 Toronto/ Ontario, Canada > > > >] | |
| Behrends, J. [IRIBHN, IBMM, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies > > > >] | |
| Pesesse, X. [INSERM E9911, Faculté de Médecine , Avenue de Valombrose, 06107 Nice, Cedex 02, France > > > >] | |
| Sasaki, T. [Laboratoire de Médecine Expérimentale, Campus Erasme, route de Lennik 808, 1070 Brussels, Belgium > > > >] | |
| Penninger, J. [Laboratoire de Médecine Expérimentale, Campus Erasme, route de Lennik 808, 1070 Brussels, Belgium > > > >] | |
| Doherty, M. [IRIBHN, IBMM, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies , Belgium > > > >] | |
| Malaisse, W. [IRIBHN, IBMM, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies , Belgium > > > >] | |
| Dumont, J. E. [IRIBHN, IBMM, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies , Belgium > > > >] | |
| Le Marchand-Bruste, Y. [University of Toronto, University Avenue 620, M5G 2C1 Toronto/ Ontario, Canada > > > >] | |
| Erneux, C. [INSERM E9911, Faculté de Médecine , Avenue de Valombrose, 06107 Nice, Cedex 02, France > > > >] | |
| Hue, L. [IRIBHN, IBMM, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies , Belgium > > > >] | |
Schurmans, Stéphane  [Université Libre de Bruxelles - ULB > Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire > > >] | |
| 2001 | |
| Nature | |
| Nature Publishing Group | |
| 409 | |
| 92-97 | |
| Yes (verified by ORBi) | |
| International | |
| 0028-0836 | |
| 1476-4687 | |
| Basingstoke | |
| United Kingdom | |
| [en] Insulin is the primary hormone involved in glucose homeostasis, and impairment of insulin action and/or secretion has a critical role in the pathogenesis of diabetes mellitus. Type-II SH2-domain-containing inositol 5-phosphatase, or 'SHIP2', is a member of the inositol polyphosphate 5-phosphatase family. In vitro studies have shown that SHIP2, in response to stimulation by numerous growth factors and insulin, is closely linked to signalling events mediated by both phosphoinositide-3-OH kinase and Ras/mitogen-activated protein kinase. Here we report the generation of mice lacking the SHIP2 gene. Loss of SHIP2 leads to increased sensitivity to insulin, which is characterized by severe neonatal hypoglycaemia, deregulated expression of the genes involved in gluconeogenesis, and perinatal death. Adult mice that are heterozygous for the SHIP2 mutation have increased glucose tolerance and insulin sensitivity associated with an increased recruitment of the GLUT4 glucose transporter and increased glycogen synthesis in skeletal muscles. Our results show that SHIP2 is a potent negative regulator of insulin signalling and insulin sensitivity in vivo | |
| Researchers ; Professionals | |
| http://hdl.handle.net/2268/4960 |
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