Reference : Endocannabinoid signaling controls pyramidal cell specification and long-range axon p...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/4930
Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning.
English
Mulder, Jan [> > > >]
Aguado, Tania [> > > >]
Keimpema, Erik [> > > >]
Barabas, Klaudia [> > > >]
Ballester Rosado, Carlos J [> > > >]
Nguyen, Laurent mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Monory, Krisztina [> > > >]
Marsicano, Giovanni [> > > >]
Di Marzo, Vincenzo [> > > >]
Hurd, Yasmin L [> > > >]
Guillemot, Francois [National Institute for Medical Research > Molecular Neurobiology > > >]
Mackie, Ken [> > > >]
Lutz, Beat [> > > >]
Guzman, Manuel [> > > >]
Lu, Hui-Chen [> > > >]
Galve-Roperh, Ismael [> > > >]
Harkany, Tibor [> > > >]
2008
Proceedings of the National Academy of Sciences of the United States of America
National Academy of Sciences
105
25
8760-5
Yes (verified by ORBi)
International
0027-8424
1091-6490
Washington
DC
[en] Animals ; Axons/metabolism ; Cell Differentiation ; Endocannabinoids/metabolism ; Female ; Humans ; Mice ; Mice, Transgenic ; Pregnancy ; Pyramidal Cells/cytology/metabolism ; Receptors, Cannabinoid/antagonists & inhibitors/genetics/metabolism ; Signal Transduction
[en] Endocannabinoids (eCBs) have recently been identified as axon guidance cues shaping the connectivity of local GABAergic interneurons in the developing cerebrum. However, eCB functions during pyramidal cell specification and establishment of long-range axonal connections are unknown. Here, we show that eCB signaling is operational in subcortical proliferative zones from embryonic day 12 in the mouse telencephalon and controls the proliferation of pyramidal cell progenitors and radial migration of immature pyramidal cells. When layer patterning is accomplished, developing pyramidal cells rely on eCB signaling to initiate the elongation and fasciculation of their long-range axons. Accordingly, CB(1) cannabinoid receptor (CB(1)R) null and pyramidal cell-specific conditional mutant (CB(1)R(f/f,NEX-Cre)) mice develop deficits in neuronal progenitor proliferation and axon fasciculation. Likewise, axonal pathfinding becomes impaired after in utero pharmacological blockade of CB(1)Rs. Overall, eCBs are fundamental developmental cues controlling pyramidal cell development during corticogenesis.
Researchers ; Students
http://hdl.handle.net/2268/4930
10.1073/pnas.0803545105

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