Reference : Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/4928
Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.
English
Heng, Julian Ik-Tsen [National Institute for Medical Research > Molecular Neurobiology > > >]
Nguyen, Laurent mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Castro, Diogo S [National Institute for Medical Research > Molecular Neurobiology > > >]
Zimmer, Celine [National Institute for Medical Research > Molecular Neurobiology > > >]
Wildner, Hendrik [National Institute for Medical Research > Molecular Neurobiology > > >]
Armant, Olivier [National Institute for Medical Research > Molecular Neurobiology > > >]
Skowronska-Krawczyk, Dorota [> > > >]
Bedogni, Francesco [> > > >]
Matter, Jean-Marc [> > > >]
Hevner, Robert [> > > >]
Guillemot, Francois [National Institute for Medical Research > Molecular Neurobiology > > >]
2008
Nature
Nature Publishing Group
455
7209
114-8
Yes (verified by ORBi)
International
0028-0836
1476-4687
Basingstoke
United Kingdom
[en] 3' Untranslated Regions/genetics ; Animals ; Basic Helix-Loop-Helix Transcription Factors/deficiency/genetics/metabolism ; Cell Movement ; Cell Shape ; Cerebral Cortex/cytology/embryology/metabolism ; Enhancer Elements, Genetic/genetics ; Gene Deletion ; Gene Expression Regulation, Developmental ; Mice ; Nerve Tissue Proteins/deficiency/genetics/metabolism ; Neurons/cytology/metabolism ; RNA Interference ; rho GTP-Binding Proteins/deficiency/genetics/metabolism
[en] Motility is a universal property of newly generated neurons. How cell migration is coordinately regulated with other aspects of neuron production is not well understood. Here we show that the proneural protein neurogenin 2 (Neurog2), which controls neurogenesis in the embryonic cerebral cortex, directly induces the expression of the small GTP-binding protein Rnd2 (ref. 3) in newly generated mouse cortical neurons before they initiate migration. Rnd2 silencing leads to a defect in radial migration of cortical neurons similar to that observed when the Neurog2 gene is deleted. Remarkably, restoring Rnd2 expression in Neurog2-mutant neurons is sufficient to rescue their ability to migrate. Our results identify Rnd2 as a novel essential regulator of neuronal migration in the cerebral cortex and demonstrate that Rnd2 is a major effector of Neurog2 function in the promotion of migration. Thus, a proneural protein controls the complex cellular behaviour of cell migration through a remarkably direct pathway involving the transcriptional activation of a small GTP-binding protein.
Researchers ; Students
http://hdl.handle.net/2268/4928
10.1038/nature07198

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