Article (Scientific journals)
Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.
Heng, Julian Ik-Tsen; Nguyen, Laurent; Castro, Diogo S et al.
2008In Nature, 455 (7209), p. 114-8
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Keywords :
3' Untranslated Regions/genetics; Animals; Basic Helix-Loop-Helix Transcription Factors/deficiency/genetics/metabolism; Cell Movement; Cell Shape; Cerebral Cortex/cytology/embryology/metabolism; Enhancer Elements, Genetic/genetics; Gene Deletion; Gene Expression Regulation, Developmental; Mice; Nerve Tissue Proteins/deficiency/genetics/metabolism; Neurons/cytology/metabolism; RNA Interference; rho GTP-Binding Proteins/deficiency/genetics/metabolism
Abstract :
[en] Motility is a universal property of newly generated neurons. How cell migration is coordinately regulated with other aspects of neuron production is not well understood. Here we show that the proneural protein neurogenin 2 (Neurog2), which controls neurogenesis in the embryonic cerebral cortex, directly induces the expression of the small GTP-binding protein Rnd2 (ref. 3) in newly generated mouse cortical neurons before they initiate migration. Rnd2 silencing leads to a defect in radial migration of cortical neurons similar to that observed when the Neurog2 gene is deleted. Remarkably, restoring Rnd2 expression in Neurog2-mutant neurons is sufficient to rescue their ability to migrate. Our results identify Rnd2 as a novel essential regulator of neuronal migration in the cerebral cortex and demonstrate that Rnd2 is a major effector of Neurog2 function in the promotion of migration. Thus, a proneural protein controls the complex cellular behaviour of cell migration through a remarkably direct pathway involving the transcriptional activation of a small GTP-binding protein.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Heng, Julian Ik-Tsen;  National Institute for Medical Research > Molecular Neurobiology
Nguyen, Laurent  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Castro, Diogo S;  National Institute for Medical Research > Molecular Neurobiology
Zimmer, Celine;  National Institute for Medical Research > Molecular Neurobiology
Wildner, Hendrik;  National Institute for Medical Research > Molecular Neurobiology
Armant, Olivier;  National Institute for Medical Research > Molecular Neurobiology
Skowronska-Krawczyk, Dorota
Bedogni, Francesco
Matter, Jean-Marc
Hevner, Robert
Guillemot, Francois;  National Institute for Medical Research > Molecular Neurobiology
Language :
English
Title :
Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.
Publication date :
2008
Journal title :
Nature
ISSN :
0028-0836
eISSN :
1476-4687
Publisher :
Nature Publishing Group, Basingstoke, United Kingdom
Volume :
455
Issue :
7209
Pages :
114-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 January 2009

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