Article (Scientific journals)
Neurotransmitters regulate cell migration in the telencephalon
Heng, J. I. T.; Moonen, Gustave; Nguyen, Laurent
2007In European Journal of Neuroscience, 26 (3), p. 537-546
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Keywords :
cerebral cortex; neurotransmitters; radial migration; rostral migratory stream; tangential migration
Abstract :
[en] The complex cytoarchitectonic organization of the adult mammalian telencephalon reflects the elaborate patterns of cell migration that contribute to its generation. The migration by neurons in the CNS can broadly be divided into two categories: radial and tangential. Experimental observations in the telencephalon have shown that glutamatergic projection neurons are born in the progenitor compartment of the dorsal telencephalon and migrate radially to integrate the cortical plate, whereas most gamma-aminobutyric acid (GABA)ergic interneurons are generated in the ganglionic eminences and navigate through multiple tangential paths to settle into distinct telencephalic structures. Despite progress towards the understanding of the genetic determinants that specify the fate of neuronal progenitors, much remains unknown about the mechanisms that direct their migration into specific regions of the telencephalon. Interestingly, besides their function in synaptic transmission, neurotransmitters have been shown to promote several developmental processes that contribute to the establishment and maintenance of the CNS. In this respect, recent studies have highlighted a role for neurotransmitters through activation of their receptors in regulating cell migration in the telencephalon. This review summarizes and discusses the growing body of literature implicating neurotransmitters and their cognate receptors as part of a complex molecular machinery that regulate the migration of immature neurons in the telencephalon during development and in adulthood.
Disciplines :
Biochemistry, biophysics & molecular biology
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Heng, J. I. T.;  National Institute for Medical Research > Molecular Neurobiology
Moonen, Gustave  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine
Nguyen, Laurent  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Language :
English
Title :
Neurotransmitters regulate cell migration in the telencephalon
Publication date :
August 2007
Journal title :
European Journal of Neuroscience
ISSN :
0953-816X
eISSN :
1460-9568
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
26
Issue :
3
Pages :
537-546
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 January 2009

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