Article (Scientific journals)
Protein tyrosine phosphatases in T cell physiology.
Mustelin, Tomas; Alonso, Andres; Bottini, Nunzio et al.
2004In Molecular Immunology, 41 (6-7), p. 687-700
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Keywords :
Antigens, CD45/immunology/physiology; Dual Specificity Phosphatase 3; Endoplasmic Reticulum/physiology; Humans; Mitogen-Activated Protein Kinases/immunology/physiology; Phosphorylation; Protein Tyrosine Phosphatases/immunology/physiology; T-Lymphocytes/enzymology/immunology; src-Family Kinases/immunology/physiology
Abstract :
[en] The molecular mechanisms of signal transduction have been the focus of intense research during the last decade. In T cells, much of the work has centered on protein tyrosine kinase-mediated signaling from the TCR and cytokine receptors, while the study of protein tyrosine phosphatases has lagged behind. Nevertheless, it has now become clear that many protein tyrosine phosphatases play equally important roles in T cell physiology and that no kinase-regulated system would work without the counterbalancing participation of phosphatases. In fact, we have learned that many processes are regulated primarily on the phosphatase side. This minireview summarizes the current state-of-the art in our understanding of the regulation and biology of protein tyrosine phosphatases in T lymphocyte physiology.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Mustelin, Tomas
Alonso, Andres
Bottini, Nunzio
Huynh, Huong
Rahmouni, Souad  ;  Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Transplantation
Nika, Konstantina
Louis-dit-Sully, Christine
Tautz, Lutz
Togo, Summanuna H
Bruckner, Shane
Mena-Duran, Armando V
al-Khouri, Anna Maria
Language :
English
Title :
Protein tyrosine phosphatases in T cell physiology.
Publication date :
2004
Journal title :
Molecular Immunology
ISSN :
0161-5890
Publisher :
Pergamon-Elsevier Science Ltd, Oxford, United Kingdom
Volume :
41
Issue :
6-7
Pages :
687-700
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 January 2009

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