Reference : Protein tyrosine phosphatases in T cell physiology.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/4880
Protein tyrosine phosphatases in T cell physiology.
English
Mustelin, Tomas [> > > >]
Alonso, Andres [> > > >]
Bottini, Nunzio [> > > >]
Huynh, Huong [> > > >]
Rahmouni, Souad mailto [Université de Liège - ULg > Département des sciences cliniques > Immunopathologie - Transplantation >]
Nika, Konstantina [> > > >]
Louis-dit-Sully, Christine [> > > >]
Tautz, Lutz [> > > >]
Togo, Summanuna H [> > > >]
Bruckner, Shane [> > > >]
Mena-Duran, Armando V [> > > >]
al-Khouri, Anna Maria [> > > >]
2004
Molecular Immunology
Pergamon-Elsevier Science Ltd
41
6-7
687-700
Yes (verified by ORBi)
International
0161-5890
Oxford
United Kingdom
[en] Antigens, CD45/immunology/physiology ; Dual Specificity Phosphatase 3 ; Endoplasmic Reticulum/physiology ; Humans ; Mitogen-Activated Protein Kinases/immunology/physiology ; Phosphorylation ; Protein Tyrosine Phosphatases/immunology/physiology ; T-Lymphocytes/enzymology/immunology ; src-Family Kinases/immunology/physiology
[en] The molecular mechanisms of signal transduction have been the focus of intense research during the last decade. In T cells, much of the work has centered on protein tyrosine kinase-mediated signaling from the TCR and cytokine receptors, while the study of protein tyrosine phosphatases has lagged behind. Nevertheless, it has now become clear that many protein tyrosine phosphatases play equally important roles in T cell physiology and that no kinase-regulated system would work without the counterbalancing participation of phosphatases. In fact, we have learned that many processes are regulated primarily on the phosphatase side. This minireview summarizes the current state-of-the art in our understanding of the regulation and biology of protein tyrosine phosphatases in T lymphocyte physiology.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/4880
10.1016/j.molimm.2004.04.015

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