Quantitative Relationship between Sensitivity to Beta-Lactam Antibiotics and Beta-Lactamase Production in Gram-Negative Bacteria--II. Non-Steady-State Treatment and Progress Curves
[en] A non-steady-state model is discussed for the study of the interplay between beta-lactamase activity and outer membrane permeability with slowly hydrolysed beta-lactams. The analysis shows: (1) that the simple, steady-state model presented in the accompanying paper remains valid as long as kcat (i.e. k3 with chromosome-encoded class C beta-lactamases) is larger than 10(-3)/sec (generation time = 20 min or more); (2) that among the beta-lactam antibiotics studied here, the complete, non-steady-state model needs only be used in the case of aztreonam; (3) that the term "trapping" should be replaced by "formation of a covalent acyl-enzyme" and that such a phenomenon only contributes significantly to the resistance when penetration and hydrolysis are very slow and the periplasmic beta-lactamase concentration is very high. Aztreonam seems to be the only compound which fulfils the first two conditions.
Disciplines :
Chemical engineering
Author, co-author :
Frère, Jean-Marie ; Université de Liège - ULiège > Département des sciences de la vie > Département des sciences de la vie
Joris, Bernard ; Université de Liège - ULiège > Centre d'ingénierie des protéines
Crine, Michel ; Université de Liège - ULiège > Département de chimie appliquée > Génie chimique - Opérations physiques unitaires
Martin, H. H.
Language :
English
Title :
Quantitative Relationship between Sensitivity to Beta-Lactam Antibiotics and Beta-Lactamase Production in Gram-Negative Bacteria--II. Non-Steady-State Treatment and Progress Curves
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