Article (Scientific journals)
Loss of calcyphosin gene expression in mouse and other rodents
Clément, S.; Dumont, J.; Schurmans, Stéphane
1997In Biochemical and Biophysical Research Communications, 232, p. 407-413
Peer reviewed
 

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Keywords :
calcyphosin; gene; mouse
Abstract :
[en] alcyphosine-for calcium binding and regulated by cyclic AMP through phosphorylation protein-is a target of both the cyclic AMP and the Ca(+2)-phophatidylinositol cascades first isolated from dog thyroid, and then from rabbit and human brain. Although the exact function of this 24kD protein is unknown, calcyphosine could be implicated in the cross-signaling between these cascades to coordinate cellular proliferation and differentiation. Here, we report the sequence of a pseudogene which is the murine calcyphosine homologue, and demonstrate that it represents the unique sequence homologous to the dog calcyphosine gene in the murine genome. The lack of expression of this murine pseudogene in brain and thyroid-two major sites of dog calcyphosine expression-was extended to 5 other rodents, and suggest the existence of alternative pathway(s) to fill the function of calcyphosine in rodents
Disciplines :
Biochemistry, biophysics & molecular biology
Genetics & genetic processes
Author, co-author :
Clément, S.;  Université Libre de Bruxelles - ULB
Dumont, J.;  Université Libre de Bruxelles - ULB
Schurmans, Stéphane  ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Biochimie métabolique vétérinaire
Language :
English
Title :
Loss of calcyphosin gene expression in mouse and other rodents
Publication date :
1997
Journal title :
Biochemical and Biophysical Research Communications
ISSN :
0006-291X
eISSN :
1090-2104
Publisher :
Academic Press, San Diego, United States - California
Volume :
232
Pages :
407-413
Peer reviewed :
Peer reviewed
Available on ORBi :
since 15 January 2010

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