ORBi: Clément S. - Loss of calcyphosin gene expression in mouse and other rodents

Reference : Loss of calcyphosin gene expression in mouse and other rodents


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology Life sciences : Genetics & genetic processes
	To cite this reference:	http://hdl.handle.net/2268/4860

Title :	Loss of calcyphosin gene expression in mouse and other rodents
Language :	English
Author, co-author :	Clément, S. [Université Libre de Bruxelles - ULB > > > >]
	Dumont, J. [Université Libre de Bruxelles - ULB > > > >]
	Schurmans, Stéphane [Université de Liège - ULg > Département de sciences fonctionnelles > Biochimie métabolique vétérinaire >]
Publication date :	1997
Journal title :	Biochemical and Biophysical Research Communications
Publisher :	Academic Press
Volume :	232
Pages :	407-413
Audience :	International
ISSN :	0006-291X
e-ISSN :	1090-2104
City :	San Diego
Country :	CA
Keywords :	[en] calcyphosin ; gene ; mouse
Abstract :	[en] alcyphosine-for calcium binding and regulated by cyclic AMP through phosphorylation protein-is a target of both the cyclic AMP and the Ca(+2)-phophatidylinositol cascades first isolated from dog thyroid, and then from rabbit and human brain. Although the exact function of this 24kD protein is unknown, calcyphosine could be implicated in the cross-signaling between these cascades to coordinate cellular proliferation and differentiation. Here, we report the sequence of a pseudogene which is the murine calcyphosine homologue, and demonstrate that it represents the unique sequence homologous to the dog calcyphosine gene in the murine genome. The lack of expression of this murine pseudogene in brain and thyroid-two major sites of dog calcyphosine expression-was extended to 5 other rodents, and suggest the existence of alternative pathway(s) to fill the function of calcyphosine in rodents
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/4860
DOI :	10.1006/bbrc.1997.6297

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