Reference : A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/4854
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.
English
Bottini, Nunzio [> > > >]
Musumeci, Lucia [> > > >]
Alonso, Andres [> > > >]
Rahmouni, Souad mailto [Université de Liège - ULg > Département des sciences cliniques > Immunopathologie - Transplantation >]
Nika, Konstantina [> > > >]
Rostamkhani, Masoud [> > > >]
MacMurray, James [> > > >]
Meloni, Gian Franco [> > > >]
Lucarelli, Paola [> > > >]
Pellecchia, Maurizio [> > > >]
Eisenbarth, George S [> > > >]
Comings, David [> > > >]
Mustelin, Tomas [> > > >]
2004
Nature Genetics
Nature Publishing Group
36
4
337-8
Yes (verified by ORBi)
International
1061-4036
1546-1718
New York
NY
[en] Diabetes Mellitus, Type 1/enzymology/genetics ; Genetic Markers ; Humans ; Polymorphism, Single Nucleotide ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatases/genetics/metabolism
[en] We report that a single-nucleotide polymorphism (SNP) in the gene (PTPN22) encoding the lymphoid protein tyrosine phosphatase (LYP), a suppressor of T-cell activation, is associated with type 1 diabetes mellitus (T1D). The variants encoded by the two alleles, 1858C and 1858T, differ in a crucial amino acid residue involved in association of LYP with the negative regulatory kinase Csk. Unlike the variant encoded by the more common allele 1858C, the variant associated with T1D does not bind Csk.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/4854
10.1038/ng1323

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Lyp paper.pdfAuthor postprint6.24 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.