Reference : Transient modifications of respiratory capacity in thymic cells during murine radiole...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/4848
Transient modifications of respiratory capacity in thymic cells during murine radioleukemogenesis
English
Verlaet, Myriam mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Service administratif de la Faculté (Médecine) >]
Duyckaerts, Claire mailto [Université de Liège - ULg > > Centre de l'oxygène : Recherche et développement (C.O.R.D.) >]
Rahmouni, Souad mailto [Université de Liège - ULg > Département des sciences cliniques > Immunopathologie - Transplantation >]
Denis, Ghislaine [> > > >]
Humblet, Chantal mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Greimers, Roland mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Sluse, Francis mailto [Université de Liège - ULg > Département des sciences de la vie > Bioénergétique et physiologie cellulaire >]
Boniver, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques]
Defresne, Marie-Paule mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
1-Jul-2002
Free Radical Biology & Medicine
Pergamon-Elsevier Science Ltd
33
1
76-82
Yes (verified by ORBi)
International
0891-5849
Oxford
United Kinggom
[en] mitochondria ; radioleukemogenesis ; oxidative DNA damage ; ROS ; thymus ; preneoplasia ; free radicals
[en] The evolution of mitochondrial oxidative phosphorylation was studied during cancer induction in a model of thymic radiolymphomagenesis in C57BL/Ka mice. During the preneoplastic period, thymuses displayed an increase of the cytochrome c oxidase activity and oxygen consumption together with oxidative DNA damage assessed by the presence of the 8-hydroxydeoxyguanine DNA base modification. These transient changes in mitochondrial functional activity were not observed in thymuses of mice rescued from lymphoma development by a bone marrow graft, suggesting an important role of mitochondria for neoplastic transformation in this model. which might therefore be of interest to test the utilization of antioxidants for the prevention of radiation-induced malignancies. (C) 2002 Elsevier Science Inc.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/4848
also: http://hdl.handle.net/2268/33031
10.1016/S0891-5849(02)00858-4

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