Article (Scientific journals)
Role of protein tyrosine phosphatases in T cell activation.
Mustelin, Tomas; Rahmouni, Souad; Bottini, Nunzio et al.
2003In Immunological Reviews, 191, p. 139-47
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Keywords :
Animals; Antigens, CD45/physiology; Autoimmune Diseases/metabolism; Humans; Protein Tyrosine Phosphatases/physiology; Signal Transduction/physiology; T-Lymphocytes/enzymology
Abstract :
[en] The last decade has seen an exponentially increasing interest in the molecular mechanisms of signal transduction. In T cells, much of the focus has been on protein tyrosine kinase (PTK)-mediated signaling from the T cell receptor (TCR) and cytokine receptors, while the study of protein tyrosine phosphatases (PTPases) has lagged behind. However, recent discoveries have revealed that several PTPases play important roles in many different aspects of T cell physiology. We predict that the phosphatases will become a 'hot topic' in the field within the next few years. This review summarizes the current understanding of the regulation and biology of PTPases in T lymphocyte activation.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Mustelin, Tomas;  Burnham Institute > Cancer Research Center
Rahmouni, Souad  ;  Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Transplantation
Bottini, Nunzio;  Burnham Institute > Cancer Research Center
Alonso, Andres;  Burnham Institute > Cancer Research Center
Language :
English
Title :
Role of protein tyrosine phosphatases in T cell activation.
Publication date :
2003
Journal title :
Immunological Reviews
ISSN :
0105-2896
eISSN :
1600-065X
Publisher :
Munksgaard International Publishers, Copenhagen, Denmark
Volume :
191
Pages :
139-47
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 January 2009

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