Reference : Les glioblastomes, un exemple de recherche translationnelle?
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/4819
Les glioblastomes, un exemple de recherche translationnelle?
French
[en] Glioblastoma, an example of translational research?
Kroonen, Jérôme mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Nguyen-Khac, Minh-Tuan mailto [Université de Liège - ULg > Département des sciences cliniques > Neurochirurgie >]
Deprez, Manuel [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Rogister, Bernard mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Robe, Pierre mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Génétique générale et humaine - Département des sciences biomédicales et précliniques >]
2008
Revue Médicale de Liège
63
5-6
251-6
Yes (verified by ORBi)
International
0370-629X
Belgium
[en] Biomedical Research ; Brain Neoplasms/pathology ; Glioblastoma/pathology ; Humans ; Neoplasm Recurrence, Local/pathology ; Neoplastic Stem Cells
[en] Among patients which develop glioblastoma multiform (GBM), recurrence is the rule despite continuous progress in surgery, radiotherapy and chemotherapy. In the adult, GBM is the most frequent and most aggressive tumour of the Central Nervous System. A better understanding of the mechanisms by which these tumours relapse could promote the use of preventive therapy and could increase patients' survival. GBM stem cells have been recently described and it was demonstrated that they are specifically implied in the experimental tumorigenesis. It is thus very attractive to speculate on a possible relationship between these GBM stem cells and the neural stem cells which are persisting in the neurogenic zones of the adult brain. In this review, we formulate and discuss the hypothesis by which, in a patient with GBM, malignant stem cells might be present in the neurogenic zones, away from the tumour mass. This hypothesis could explain the tumour relapse observed after the first treatments.
http://hdl.handle.net/2268/4819

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Kroonen-Revue Médicale de Liège,2008.pdfNo commentaryPublisher postprint1.62 MBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.