Reference : Cyclo-oxygenase type 2-dependent prostaglandin E-2 secretion is involved in retrovirus-i...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/4809
Cyclo-oxygenase type 2-dependent prostaglandin E-2 secretion is involved in retrovirus-induced T-cell dysfunction in mice
English
Rahmouni, Souad mailto [Université de Liège - ULg > Département des sciences cliniques > Immunopathologie - Transplantation >]
Aandahl, Einar Martin [University of Oslo > Biotechnology Centre of Oslo]
Nayjib, Btissam mailto [> > > >]
Zeddou, Mustapha mailto [Université de Liège - ULg > Département des sciences cliniques > Hématologie >]
Giannini, Sandra mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Verlaet, Myriam mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Service administratif de la Faculté (Médecine) >]
Greimers, Roland mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Boniver, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques]
Tasken, Kjetil [University of Oslo > Biotechnology Centre of Oslo]
Moutschen, Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Immunopathologie - Transplantation]
15-Dec-2004
Biochemical Journal
Portland Press
384
Pt 3
469-476
Yes (verified by ORBi)
International
0264-6021
1470-8728
London
[en] cAMP ; cyclo-oxygenase type 2 ; immunodeficiency ; prostaglandin E-2 ; retroviral infection ; T-cell
[en] MAIDS (murine AIDS) is caused by infection with the murine leukaemia retrovirus RadLV-Rs and is characterized by a severe immunodeficiency and T-cell anergy combined with a lymphoproliferative disease affecting both B- and T-cells. Hyperactivation of the cAMP-protein kinase A pathway is involved in the T-cell dysfunction of MAIDS and HIV by inhibiting T-cell activation through the T-cell receptor. In the present study, we show that MAIDS involves a strong and selective up-regulation of cyclo-oxygenase type 2 in the CD11b+ subpopulation of T- and B-cells of the lymph nodes, leading to increased levels of PGE2 (prostaglandin E2). PGE2 activates the cAMP pathway through G-protein-coupled receptors. Treatment with cyclo-oxygenase type 2 inhibitors reduces the level of PGE2 and thereby reverses the T-cell anergy, restores the T-cell immune function and ameliorates the lymphoproliferative disease.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/4809
10.1042/BJ20031859

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