Article (Scientific journals)
Cyclo-oxygenase type 2-dependent prostaglandin E-2 secretion is involved in retrovirus-induced T-cell dysfunction in mice
Rahmouni, Souad; Aandahl, Einar Martin; Nayjib, Btissam et al.
2004In Biochemical Journal, 384 (Pt 3), p. 469-476
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Keywords :
cAMP; cyclo-oxygenase type 2; immunodeficiency; prostaglandin E-2; retroviral infection; T-cell
Abstract :
[en] MAIDS (murine AIDS) is caused by infection with the murine leukaemia retrovirus RadLV-Rs and is characterized by a severe immunodeficiency and T-cell anergy combined with a lymphoproliferative disease affecting both B- and T-cells. Hyperactivation of the cAMP-protein kinase A pathway is involved in the T-cell dysfunction of MAIDS and HIV by inhibiting T-cell activation through the T-cell receptor. In the present study, we show that MAIDS involves a strong and selective up-regulation of cyclo-oxygenase type 2 in the CD11b+ subpopulation of T- and B-cells of the lymph nodes, leading to increased levels of PGE2 (prostaglandin E2). PGE2 activates the cAMP pathway through G-protein-coupled receptors. Treatment with cyclo-oxygenase type 2 inhibitors reduces the level of PGE2 and thereby reverses the T-cell anergy, restores the T-cell immune function and ameliorates the lymphoproliferative disease.
Disciplines :
Immunology & infectious disease
Author, co-author :
Rahmouni, Souad  ;  Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Transplantation
Aandahl, Einar Martin;  University of Oslo > Biotechnology Centre of Oslo
Nayjib, Btissam 
Zeddou, Mustapha ;  Université de Liège - ULiège > Département des sciences cliniques > Hématologie
Giannini, Sandra ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Verlaet, Myriam ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Service administratif de la Faculté (Médecine)
Greimers, Roland ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Boniver, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Tasken, Kjetil;  University of Oslo > Biotechnology Centre of Oslo
Moutschen, Michel  ;  Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Transplantation
Language :
English
Title :
Cyclo-oxygenase type 2-dependent prostaglandin E-2 secretion is involved in retrovirus-induced T-cell dysfunction in mice
Publication date :
15 December 2004
Journal title :
Biochemical Journal
ISSN :
0264-6021
eISSN :
1470-8728
Publisher :
Portland Press, London, United Kingdom
Volume :
384
Issue :
Pt 3
Pages :
469-476
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 January 2009

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