ORBi: Schurmans Stéphane - Anti-LFA-1 (CD11a) monoclonal antibody interferes with the induction of neonatal tolerance to alloantigens

Reference : Anti-LFA-1 (CD11a) monoclonal antibody interferes with the induction of neonatal toleran...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology Life sciences : Genetics & genetic processes
	To cite this reference:	http://hdl.handle.net/2268/4781

Title :	Anti-LFA-1 (CD11a) monoclonal antibody interferes with the induction of neonatal tolerance to alloantigens
Language :	English
Author, co-author :	Schurmans, Stéphane [Université Libre de Bruxelles - ULB > Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Institut de Biologie et de Médecine Moléculaire > > >]
	Gonzalez, A. [WHO Immunology Research and Training Center, Department of Pathology, CMU, University of Geneva > > > >]
	Revilla, C. [WHO Immunology Research and Training Center, Department of Pathology, CMU, University of Geneva > > > >]
	Ramos, A. [WHO Immunology Research and Training Center, Department of Pathology, CMU, University of Geneva > > > >]
	Lambert, P. H. [WHO Immunology Research and Training Center, Department of Pathology, CMU, University of Geneva > > > >]
	Merino, J. [WHO Immunology Research and Training Center, Department of Pathology, CMU, University of Geneva > > > >]
Publication date :	1994
Journal title :	European Journal of Immunology
Publisher :	VCH Verlagsgesellschaft
Volume :	24
Pages :	985-990
Audience :	International
ISSN :	0014-2980
City :	Weinheim
Country :	Germany
Abstract :	[en] The injection of (C57BL/6 x BALB/c)F1 spleen cells into newborn BALB/c mice results in the induction of a specific cytotoxic T lymphocyte (CTL) tolerance to the alloantigens. On the contrary, alloreactive CD4+ T cells persist in the host and are still able to activate autoreactive F1 B cells to produce autoantibodies. This state of "split tolerance" is closely associated with the development of a lupus-like autoimmune syndrome. The LFA-1 integrin plays a relevant role in homing, intercellular adhesion and tranduction of co-stimulatory signals in leukocytes. Because of the beneficial effects of anti-LFA-1 monoclonal antibodies (mAb) treatment in various models of organ transplantation and autoimmune disease, we have investigated if such a treatment could interfere with the induction of neonatal tolerance or the development of the autoimmune syndrome in F1 cell-injected newborn mice. For this purpose, BALB/c mice neonatally injected with F1 cells were treated from day 1 up to day 15 with a non-cytotoxic anti-LFA-1 (CD11a) mAb. Anti-LFA-1 mAb treatment interfered with the persistence of a stable chimerism and with the establishment of CTL tolerance, as shown by rejection of allogeneic skin grafts and F1 B cells, and by a normal in vitro CTL activity against the corresponding alloantigens. As a consequence, these mice did not develop the characteristic autoimmune features seen in close association with an effective induction of CTL tolerance to alloantigens. These results stress the importance of the interactions between LFA-1 and its ligands during the neonatal induction of tolerance to alloantigens
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/4781

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