Reference : Hemodynamic effects of epinephrine associated to an epidural clonidine-bupivacaine mixtu...
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
http://hdl.handle.net/2268/4771
Hemodynamic effects of epinephrine associated to an epidural clonidine-bupivacaine mixture during combined lumbar epidural and general anesthesia.
English
Senard, Marc mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Ledoux, Didier mailto [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
Darmont, Pascaline [Centre Hospitalier Universitaire de Liège - CHU > > HOSPITALISATION - CHIR. CARDIAQUE (SN +1A) >]
Hans, Pol [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Brichant, Jean-François mailto [Université de Liège - ULg > Département des sciences cliniques > Anesthésie et réanimation >]
Bonnet, Fabienne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais généraux et de personnel >]
1998
Acta Anaesthesiologica Belgica
Acta Medica Belgica
49
3
167-73
Yes (verified by ORBi)
International
0001-5164
Bruxelles
Belgique
[en] Adolescent ; Adrenergic alpha-Agonists/administration & dosage ; Adult ; Aged ; Analgesia, Epidural ; Analysis of Variance ; Anesthesia, Epidural ; Anesthesia, General ; Anesthetics, Local/administration & dosage ; Blood Pressure/drug effects ; Bupivacaine/administration & dosage ; Chi-Square Distribution ; Clonidine/administration & dosage ; Double-Blind Method ; Epinephrine/administration & dosage ; Female ; Heart Rate/drug effects ; Humans ; Intervertebral Disk/surgery ; Lumbar Vertebrae/surgery ; Male ; Middle Aged ; Nerve Block ; Prospective Studies
[en] Clonidine or epinephrine are frequently combined to epidural local anesthetics to strengthen sensory block and prolong analgesia. Both drugs impair the hemodynamic profile of central neural blockade but the effects of their combination on arterial pressure and heart rate are not known and were examined in this double-blind prospective randomised study. Forty four patients scheduled for lumbar disc surgery were allocated to two groups. Epidural anesthesia was obtained by administration of 150 micrograms clonidine in 15 ml bupivacaine 0.25% solution without (group C) or with (group C + E) 37.5 micrograms epinephrine. Systolic, mean, diastolic arterial pressure and heart rate were measured throughout the study. Combined epidural and general anesthesia induced a significant decrease in arterial pressure and heart rate in both groups. SAP and MAP decreased significantly less in the patients receiving epinephrine. Low dose epidural epinephrine decreases arterial pressure instability during combined epidural and general anesthesia.
http://hdl.handle.net/2268/4771
also: http://hdl.handle.net/2268/766

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