Reference : Is Alzheimer's disease a disconnection syndrome? Evidence from a crossmodal audio-vis...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/4759
Is Alzheimer's disease a disconnection syndrome? Evidence from a crossmodal audio-visual illusory experiment
English
Delbeuck, Xavier [>CHRU Lille > > > Hôpital Roger Salengro > Centre de la mémoire > >]
Collette, Fabienne mailto [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie >]
Van der Linden, Martial mailto [Université de Liège - ULg > Département des sciences cognitives > Psychopathologie cognitive >]
2007
Neuropsychologia
Pergamon-Elsevier Science Ltd
45
14
3315-3323
Yes (verified by ORBi)
International
0028-3932
Oxford
[en] Alzheimer's disease ; crossmodal integration ; brain connectivity
[en] In Alzheimer's disease (AD), loss of connectivity in the patient's brain has been evidenced by a range of electrophysiological and neuroimaging studies. However, few neuropsychological research projects have sought to interpret the cognitive modifications following the appearance of AD in terms of a disconnection syndrome. In this paper, we sought to investigate brain connectivity in AD via the study of a crossmodal effect. More precisely, we examined the integration of auditory and visual speech information (the McGurk effect) in AD patients and matched control subjects. Our results revealed impaired crossmodal integration during speech perception in AD, which was not associated with disturbances in the separate processing of auditory and visual speech stimuli. In conclusion, our data suggest the occurrence of a specific, audio-visual integration deficit in AD, which might be the consequence of a connectivity breakdown and corroborate the observation from other studies of crossmodal deficits between the auditory and visual modalities in this population. (C) 2007 Elsevier Ltd. All rights reserved.
Researchers
http://hdl.handle.net/2268/4759
10.1016/j.neuropsychologia.2007.05.001

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